甲状腺过氧化物酶抗体阳性孕妇妊娠结局及进行临床干预的必要性

Thyroid Peroxidase Antibody Positive Pregnant Women Pregnancy Outcome and the Necessity for Clinical Intervention

目的:研究甲状腺过氧化物酶抗体阳性孕妇妊娠结局及进行临床干预的必要性。方法:选取某院2013年7月~2015年6月78例单纯甲状腺过氧化物酶抗体阳性孕妇为研究对象,分为A组(给予左甲状腺素钠片干预,38例)与B组(不给予左甲状腺素钠片,40例);选取同时期50例健康孕妇作为对照组,对比3组妊娠结局。结果:A、B两组与对照组胎儿窘迫、羊水量异常、胎膜早破发生率差异存在统计学意义。结论:胎儿窘迫、羊水异常、胎膜早破与甲状腺过氧化物酶抗体阳性有关,左甲状腺素钠片干预与不干预的妊娠结局相似。

Objective： To study the pregnancy outcome of thyroid peroxidase antibody positive pregnant women and the necessity of clinical intervention. Methods： A total of 78 cases of simple thyroid peroxidase antibody positive pregnant women were divided into group A （38 cases with left thyroxine sodium intervention） and group B （ not given the left thyroxine sodium tablets, 40 cases） ; select 50 cases of healthy pregnant women during the same period as a control group, then compare the pregnancy outcome of the three groups. Results： There were significant differences in the incidence of fetal distress, amniotic fluid volume and premature rupture of membranes in group A and group B. Conclusion： Fetal distress, amniotic fluid abnormalities, premature rupture of membranes are positively associated with thyroid peroxidase antibody and pregnancy outcomes with left thyroxine sodium tablets or not are similar to each other.