多索茶碱治疗喘息性支气管炎的应用及临床有效性研究

Clinical Effectiveness Research on Doxofylline in the Treatment of Asthmatic Bronchitis

目的:研究多索茶碱治疗喘息性支气管炎的应用及临床有效性。方法:研究纳入的对象来源于2014年5月~2016年6月某院收治喘息性支气管炎患儿中随机抽取的83例,将上述83例喘息性支气管炎患儿随机分为A组41例和D组42例。A组用氨茶碱+葡萄糖注射液静注,D组用多索茶碱+葡萄糖注射液静注。比较两组临床疗效;咳嗽、喘息、咳痰持续时间和住院时间;干预前和干预后患儿免疫球蛋白E、症状积分、生活质量评分的差异。结果:(1)D组较A组临床疗效更高,P<0.05;(2)D组较A组咳嗽、喘息、咳痰持续时间和住院时间更短,P<0.05;(3)干预前两组免疫球蛋白E、症状积分、生活质量评分相似,P>0.05;干预后D组较A组免疫球蛋白E、症状积分、生活质量评分改善更显著,P<0.05。结论:多索茶碱治疗喘息性支气管炎的应用效果确切,可有效改善患儿临床症状和免疫力,缩短疗程,提升其生活质量,值得推广。

Objective： To study the effectiveness and asthmatic bronchitis. Methods： 83 cases of children with clinical application of doxofylline in the treatment of asthmatic bronchitis in a hospital from May 2014 to June 2016 were taken as the subjects, who were randomly divided into group A （n =41） and group D （n = 42）. group A were treated with intravenous injection of aminophylline ＋ Glucose Injection, group D were treated with intravenous injection of doxofylline ＋ Glucose Injection. Then Compare clinical curative effect; cough, wheezing, expectoration duration and hospitalization time; the difference of immunoglobulin E, symptom score and quality of life score before and after intervention. Results： （1） the clinical curative effect of group D was better than that of group A, P〈0.05; （2） cough, wheezing, cough duration and hospital stay of group D was shorter than those of group A, P〈0.05; （3） before the intervention, immunoglobulin E, symptom score, quality of life scores of the two groups were similar, P〉0.05; after the intervention of immune globulin protein E, symptom score, quality of life scores of group D were improved more significantly than group A, P〈0.05. Conclusion： The application effect of doxofylline in the treatment of asthmatic bronchitis is exact and obvious, which effectively improve clinical symptoms and improve patients immunity, shorten the course of treatment, improve the quality of life, worthy of promotion.