沙利度胺在肺癌化疗中改善患者食欲和体质量的作用观察

Effect of Thalidomide on Appetite and Body Weight in Patients with Lung Cancer

目的:在肺癌化疗中应用沙利度胺,观察患者的食欲与体质量改善情况。方法:将66例肺癌化疗患者随机分成对照组与观察组,对照组在化疗期间给予格拉司琼针止吐以及水化、利尿、止痛等常规治疗;观察组在对照组常规辅助治疗基础上,口服沙利度胺片,对比两组食欲、体质量改善情况。结果:观察组ECOG评分改善率为36.4%,食欲与体重改善率为39.4%,明显优于对照组,P<0.05;观察组恶心呕吐等不良反应为33.3%,对照组为57.6%,观察组明显轻于对照组,P<0.05。结论:肺癌化疗中应用沙利度胺不仅可以起到直接抗肿瘤作用,同时患者食欲与体质量改善率也明显提升,值得推广。

Objective. To investigate the use of thalidomide in the treatment of lung cancer, and to observe the improvement of appetite and body weight. Methods. 66 patients with lung cancer were randomly divided into control group and observation group. In the control group, the rats were treated with granisetron needle acupuncture and hydration, diuretic and analgesia. The observation group was treated on the routine adjuvant therapy of the control group, Oral thalidomide tablets, compared to the two groups of appetite, body weight improvement. Results. The improvement rate of ECOG score was 36.4%, the improvement rate of appetite and body weight was 39.4%, which was significantly better than that of the control group （P〈 0.05）. The adverse reactions of nausea and vomiting were 33.3 % in the observation group and 57.6% in the control group, significantly lighter than the control group, P〈0.05. Conclusion. The application of thalidomide in lung cancer chemotherapy can not only be anti-tumor effect directly, but also the appetite and body weight improvement rate of patients is also improved, it is worth promoting.