替莫唑胺联合放疗治疗胶质瘤患者的生存情况分析

Survival Analysis of Temozolomide and Radiation Therapy for Glioma Patients

目的探讨分析替莫唑胺联合放疗治疗对胶质瘤患者生存情况的影响。方法选取64例胶质瘤患者为研究对象,采用数字表法将其平均分成两组,对照组患者在术后行放疗,观察组患者在放疗基础上联合应替莫唑胺化疗,比较两组患者治疗后的生存情况及不良反应情况。结果观察组临床疾病控制率(50.00%)明显高于对照组(25.00%),有统计学意义(P<0.05);观察组患者无进展生存时间为(11.24±3.09)个月和生存时间为(15.64±3.87)个月,较对照组患者的无进展生存时间[(6.09±1.97)个月]和生存时间[(8.71±2.56)个月]明显要长,有统计学意义(P<0.05);观察组患者白细胞下降、头皮溃疡、恶心呕吐、腹泻、血小板计数下降等不良反应发生率均低于对照组,均可自行缓解或对症用药后可控制。结论胶质瘤患者术后采用替莫唑胺联合放疗治疗,与单纯的放疗相比较,能够有效控制肿瘤生长情况,延长患者无进展生存时间和总生存时间,治疗期间不良反应少,安全有效。

Objective To investigate the effect of temozolomide combined with radiotherapy on the survival of glioma pa- tients. Methods 64 cases of glioma patients were selected and equally divided into 2 groups by using the digital number method, the control group were given radiotherapy after surgery, and the observation group were treated with temozolomide chemotherapy and radiation therapy. The survival and adverse reactions between the 2 groups of patients after treatment were compared. Results Clinical disease control rate （50. 00% ） in the observation group was significantly higher than that of the control group （25.00%）, the difference was statistically significant （P 〈 0.05 ） ; the progression-free survival time （ 11.24 ± 3.09 ） months and survival time（ 15.64 ± 3.87） months in the observation group were obviously longer than those of the control group[ progression- free survival time（6.09 ± 1.97 ） months and survival time （8.71 ± 2.56） months ], the differences were statistically significant（ P 〈 0.05） ; the incidence of adverse reactions such as leukopenia, scalp ulcers, nausea, vomiting, diarrhea, and decreased platelet counts in the observation group were lower than those of the control group, all reactions can relieve itself or can be controlled by symptomatic treatment. Conclusion Postoperative temozolomide combined with radiotherapy is superior to radiotherapy alone,it can effectively control the tumor growth, prolong progression-free survival and overall survival time, induce less adverse reactions, and it is safe and effective.