自拟减毒汤联合康复新对鼻咽癌患者放疗不良反应的减毒效果观察

Observation on Attenuation Effect of Self-Designed Attenuation Decoction Combined with Kangfuxin on Side Effects of Radiotherapy in Patients with Nasopharyngeal Carcinoma

目的:探讨自拟减毒汤加减联合康复新对鼻咽癌患者放疗不良反应的减毒效果观察。方法:选取2013年7月—2015年7月接受放射治疗的鼻咽癌患者96例(完成86例,脱落10例)作为研究对象,采用随机数字表法分为观察组(48例,完成44例,脱落4例)和对照组(48例,完成42例,脱落6例),对照组给予康复新治疗,观察组在对照组基础上给予自拟减毒汤加减治疗,以放疗结束作为干预终点,记录两组放射不良反应发生率、发生时间、持续时间,采用卡氏评分(KPS)评估功能状态,计算体质量指数(BMI)。结果:观察组口腔黏膜损伤、放射性食管炎、放射性皮肤损伤、口干的Ⅲ~Ⅳ级发生率分别为20.45%、9.09%、9.09%、6.82%,明显低于对照组的42.86%、28.57%、35.71%、30.95%;观察组口腔黏膜损伤、放射性食管炎、放射性皮肤损伤、口干的出现时间长于对照组,口腔黏膜损伤、放射性食管炎、放射性皮肤损伤持续时间短于对照组(P<0.05);观察组治疗后KPS评分、BMI高于对照组(P<0.05)。结论:自拟减毒汤加减联合康复新可减轻鼻咽癌患者放疗不良反应严重程度,延长不良反应出现时间,减少对生活质量、体质量的影响。

Objective ： To investigate the attenuation effect of self - designed attenuation decoction combined with Kangfuxin on side effects of radiotherapy in patients with nasopharyngeal carcinoma. Methods ： Ninety - six patients with nasopharyngeal carcinoma who received radiotherapy between July 2013 and July 2015 were selected as the study subjects. By the random number table method, the subjects were divided into observation group （48 cases,44 cases completed,4 cases lost to follow up） and control group （48 cases,42 cases completed,6 cases lost to follow up）. The control group was treated with Kanduxin. On the basis,the observation group was treated with modified self - designed attenuation decoction. The end of radiotherapy was taken as the end of intervention. The incidence, occurrence time and duration of side effects of radiotherapy in the two groups were recorded, and the Karnofsky performance status （KPS） score was used to evaluate functional status. Results ： The incidence rates of oral mucosal in- jury,radiation esophagitis, radiation skin lesion and grade III- IV dry mouth in the observation group （20. 45% ,9.09%, 9. 09% ,6. 82% ） were much lower than those in the control group （42.86% ,28.57% ,35.71% ,30.95% ）. The occurrence time of oral mucosal injury, radiation esophagitis, radiation skin lesion and dry mouth in observation group was longer than that in the control group while the duration of oral mucosal injury, radiation esophagitis and radiation skin lesion was shorter than that in the control group （P 〈 0. 05 ）. After treatment, KPS score and BMI of the observation group were higher than those of the control group （P 〈 0. 05 ）. Conclusion ： Self - designed attenuation decoction combined with Kangfuxin can extend the occurrence time of side effects of radiotherapy in patients with nasopharyngeal carcinoma and reduce the severity and reduce the effects on quality of life and body mass.