杠板归化学成分的研究

Study on chemical constituents of Polygonum perfoliatum L.

目的研究杠板归Polygonum perfoliatum L.的化学成分。方法采用各种柱色谱包括硅胶、凝胶及制备液相等色谱分离方法进行分离纯化,经核磁共振技术进行化合物结构鉴定。结果从杠板归甲醇提取物中分离得到11个化合物,分别鉴定为长寿花糖苷(1)、4,5-二氢布卢门醇A(2)、槲皮素-3-O-β-D-吡喃葡萄糖苷(3)、槲皮素-3-O-β-D-葡萄糖醛酸-6″-甲酯(4)、槲皮素-3-O-β-D-葡萄糖醛酸苷(5)、槲皮素(6)、3,4-dihydro-5-hydroxy-7-methoxy-4-(4'-methoxyphenyl)coumarin(7)、地芰普内酯(8)、vanicoside B(9)、vanicoside A(10)、氢化胡椒苷(11)。结论化合物1、2和8为首次从该属植物中分离得到。

Objective To investigate the chemical constituents of Polygonum perfoliatum L.Methods The constituents were isolated and purified by silica gel column chromatographic and preparative HPLC technologies.The structures of the isolated compounds were elucidated by NMR spectrum.Results Eleven compounds were isolated and identified as corchoionoside C （1）,4,5-dihydroblumenol A （2）,quercetin-3-O-β-D-glucoside （3）,quercetin-3-O-β-D-glucuronide-6′′-methyl ester （4）,quercetin-3-O-β-D-glucuronopyranoside （5）,quercetin （6）,3,4-dihydro-5-hydroxy-7-methoxy-4-（4′-methoxyphenyl） coumarin （7）,loliolide （8）,vanicoside B （9）,vanicoside A （10）,hydropiperoside （11）.Conclusion Compound 1,2 and 8 are obtained from this genus for the first time.