血清IL-6、TRAIL在高血压脑出血患者中的表达及意义

The significant of serum IL-6,TRAIL and its receptors expression in patients with hypertensive cerebral hemorrhage

目的分析血清白细胞介素-6(IL-6)、肿瘤坏死因子相关凋亡诱导配体(TRAIL)在高血压脑出血患者中的表达及意义。方法选取2015年4月—2016年5月辽宁省鞍山市第三医院神经内科诊治高血压脑出血患者65例作为研究对象(观察组),同时,根据患者GCS评分的不同分为A亚组(轻度意识障碍)27例、B亚组(中度昏迷)24例、C亚组(重度昏迷)14例;此外,根据患者ADL评分不同分为Ⅰ亚组(轻度)29例、Ⅱ亚组(中度)24例、Ⅲ亚组(重度)12例,另取同期于医院正常体检者65例作为对照组,分别对比IL-6、TRAIL水平,并作相关性分析。结果观察组IL-6与TRAIL水平分别为(22.81±9.82)ng/L与(3.12±1.04)ng/ml,均显著高于对照组的(13.44±2.47)ng/L与(1.61±0.53)ng/ml(P均<0.05);随着GCS评分的逐渐升高,A、B、C亚组患者外周血IL-6、TRAIL水平均呈逐渐上升趋势,差异均有统计学意义(F=7.382、6.372,P<0.05);随着ADL评分的逐渐升高,Ⅰ、Ⅱ、Ⅲ亚组患者外周血IL-6、TRAIL水平呈逐渐下降趋势,差异均有统计学意义(F=9.428、8.374,P<0.05);高血压脑出血患者GCS评分与IL-6、TRAIL呈显著正相关(r=0.632、0.587,P<0.01),ADL评分与IL-6、TRAIL均呈显著负相关(r=-0.643、-0.619,P<0.01)。结论对高血压脑出血患者IL-6与TRAIL表达水平进行检测,可有效评估患者病情严重程度及预后情况。

Objective To study the serum interleukin 6 （IL-6）, tumor necrosis factor related apoptosis inducing ligand （TRAIL） and its receptor in patients with hypertensive cerebral hemorrhage.Methods From April 2015 to May 2016, 65 cases in department of Neurology of the Third Hospital of Anshan City of Liaoning Province were enrolled as study object.At the same time, according to different GCS score, they were divided into group A （27 cases）, group B （24 cases）, and group C （14 cases）.In addition, according to different ADL scores, they were divided into subgroupⅠ（29 cases）, subgroup Ⅱ （24 cases）, subgroup Ⅲ （12 cases）, take another 65 cases of normal physical examination for the same period as the control group.Comparative analysis of IL-6, TRAIL levels, and did correlation analysis.Results The observation group＇s IL-6 and TRAIL levels respectively were （22.81±9.82） ng/L and （3.12±1.04） ng/ml, which were significantly higher than that of control group （13.44±2.47） ng/L and （1.61±0.53） ng/ml （all P〈0.05）.With GCS score increased, peripheral blood IL-6 in group A,group B, and group C were raised gradually, the TRAIL level were statistically significant differences （all P〈0.05）.With the gradual increase of GCS score, IL-6 and TRAIL levels in peripheral blood of patients in group A, group B and group C were gradually increased, the difference was statistically significant （F=7.382,6.372,P〈0.05）.With the gradual increase of ADL score, the levels of IL-6 and TRAIL in peripheral blood of patients in group I, group II and group III were gradually decreased, and the difference were statistically significant （P〈0.05）.There was a significant positive correlation between GCS score and IL-6, TRAIL （F=7.382,6.372,P〈0.05） in patients with hypertensive intracerebral hemorrhage.There was a significant negative correlation between ADL score and IL-6, TRAIL （r=-0.643,r=-0.619, all P=0.000）.Conclusion The detection of IL-6 and TRAIL expression level in patients with hypertensive intracerebral hemorrhage can effectively evaluate the severity and prognosis of the patients.