肌酐、肌钙蛋白在不同AECOPD严重程度中的变化

Changes of Creatinine and Troponin in Patients with Different Degrees of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

目的:研究不同AECOPD严重程度中肌酐及肌钙蛋白的变化。方法:纳入2015年2月~2016年8月我院收治的164例AECOPD患者为研究对象,依据患者肺功能损伤程度以及临床表现差异分为轻度组(n=42)、中度组(n=64)、重度组(n=58),对比三组肌酐、肌钙蛋白水平,并找出其变化规律。结果:三组患者肌酐、肌钙蛋白水平对比差异具有显著性(P<0.05);随着病情加深,FEV1/预计值%减小,而肌酐、肌钙蛋白水平和FEV1/预计值%呈负相关性。结论:肌酐、肌钙蛋白水平和FEV1/预计值%呈负相关性,可将慢性阻塞性肺病患者肾功能损坏及心肌细胞损害程度体现出来。

Objective： To study the changes ofcreatinine and troponin in patients with different degrees of acute exacerbations of Chronic obstructive pulmonary disease （AECOPD）. Methods： A total of 164 patients with AECOPD were admitted and treated in our hospital from February 2015 to August 2016 as the objects of study. According to the damage degree of pulmonary function, they were divided into mild group （n=42）, moderate group （n=64）, and severe group （n=58）. The levels ofcreatinine and troponin were compared in three groups for understanding the pattern of changes.Results： There were significant differences among three groups in creatinine and troponin （P 〈 0.05）. The predicted values of FEV1 decrease as the disease got worse, but negatively related to creatinine and troponin. Conclusions： There is negative correlation between creatinine, troponin, and FEV1, which can reflect the damage degree of pulmonary function and cardiomyocytes in patients with AECOPD.