MCV、RDW和红细胞计数在地中海贫血筛查中的应用价值分析

Application Analysis of MCV,RDW,and RBC on Screening for Thalassemia

目的:探讨红细胞平均体积(MCV)、红细胞分布宽度(RDW)、红细胞计数水平三项指标联合测定对地中海贫血疾病实施筛查的临床价值研究。方法:选择我院收治的确诊为地中海贫血和普通贫血疾病的患者各48例,再选择同期接受健康体检的健康人资料48例,分别定义为研究1组、研究2组、对照组。采用全自动血细胞分析仪对三组研究对象的红细胞平均体积、红细胞分布宽度、红细胞计数三项指标水平进行测定,对比测定结果的阳性率。结果:研究1组对象MCV明显低于研究2组、对照组对象均存在显著性差异(P<0.05);研究1组对象RDW、红细胞计数水平明显高于研究2组、对照组均存在显著性差异(P<0.05);研究1组MCV阳性率(81.3%)、RDW阳性率(87.5%)、红细胞计数水平阳性率(95.8%)高于研究2组、对照组存在显著性差异(P<0.05)。结论:地中海贫血疾病患者的红细胞平均体积、红细胞分布宽度、红细胞计数水平与普通贫血患者、健康人群相比均会出现出明显异常,临床可以根据这一特征对地中海贫血疾病进行筛查。

Objective： To investigate the clinical value of MCV, RDW, and RBC on screening for thalassemia. Methods： Totally, 96 patients were admitted and treated in our hospital. They were divided group I and group U , patients with thalassemia as group [ （n=48）, while patients with anemia as group lI （n=48）. In addition, 48 healthy check-up people were selected as control group. Then MCV, RDW, and RA3C were detected by automatic blood cell analyzer, and the number of positive rate was compared among three groups. Results： MCV in group I was significantly lower than that in other two groups （P 〈 0.05）. RDW and Pd3C in group I were significantly higher than those in other two groups （P 〈 0.05）. In group I ,the positive rate in of MCV （81.3%）, RDW （87.5%）, and RBC （95.8%） were significantly higher than those in other two group （P 〈 0.05）. Conclusions： MCV, RDW, and RBC have significant abnormal abnormity in patients with thalassemia for screening.