早产儿脑损伤与妊娠期内宫内感染的相关性分析

Study of Correlation Analysis on Intrauterine Infection and Brain Injury in Preterm Infants during Pregnancy

目的:探讨早产儿脑损伤与妊娠期内宫内感染的相关性分析。方法:选取2015年2月~2016年4月在我院出生的早产儿186例,根据胎盘病理检查结果分为绒毛膜羊膜炎73例作为观察组,无绒毛膜羊膜炎113例为对照组。新生儿出生后3~5d行头颅超声检查,并在早产儿纠正胎龄为40周时行神经测定(NBNA)对比两组脐带血IL-6、IL-10、TNF-α水平,并采用Logistics分析早产儿脑损伤危险因素。结果:经超声诊断,观察组早产儿脑损伤发生率50.68%高于对照组(17.70%),差异有统计学意义(P<0.01);观察组中脑损伤早产儿脐带血L-6、IL-10、TNF-α水平较对照组中脑损伤早产儿高,差异有统计学意义(P<0.05);观察组NBNA评分(35.42±10.76)低于对照组(39.35±12.64),差异有统计学意义(P<0.05);经多因素Logistics分析显示,胎龄及宫内感染为早产儿脑损伤的高危因素(P<0.05)。结论:妊娠期内宫内感染可增大早产儿脑损伤风险,与早产儿脑损伤发生有一定的相关性。

Objective： To investigate the study of correlation analysis on intrauterine infection and brain injury in preterm infants during pregnancy. Methods： Total/y, 186 preterm infants were born in our hospital from February 2015 to April 2016 as the objects of study. They were divided into two groups by examination of placental pathology, the chorioamnionitis as test group （n=73） and the nochorioanmionitis as control group （n=113）. All newborns were performed skull MRI within 3-5 days. Meanwhile, IL-6, IL-10, TNF- α were compared by Neonatal Behavioral Neurological Assessment （NBNA）, and the risk factors of brain injury was analyzed by Logistics.Results： （1） The incidence of brain injury in test group （50.68%） was significantly higher than that in control group （17.70%） （P〈0.01）. （2） The level of L-6, IL-10, TNF- α in test group were significantly higher than those in control group （P〈0.05）. （3） The score of NBNA in test group （35.42 ＋ 10.76） was significantly lower than that in control group （39.35 ±12.64） （P〈0.05）. （4） The high risk factors of brain injury were gestational age and intrauterine infections （P〈0.05）.Conelusions： The risk of brain injury in premature infants is correlative with intrauterine infections during pregnancy.