健脾益肺方辅助治疗小儿哮喘缓解期肺脾气虚型42例临床观察

Clinical observation of therapeutic effect on Jianpi Yifei Fang in the treatment of children in remission phase of asthma with lung-spleen deficiency pattern

目的观察健脾益肺方辅助治疗哮喘缓解期肺脾气虚型患儿的临床疗效。方法将2012年7月至2016年4月于我院儿科收治的哮喘缓解期肺脾气虚型患儿随机分为对照组40例和治疗组42例,对照组给予布地奈德福莫特罗粉雾化吸入治疗,治疗组在对照组治疗方法的基础上联合健脾益肺方治疗,2组均治疗3月后统计疗效。结果治疗后2组哮喘发作情况均显著改善,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组改善幅度大于对照组(P<0.05)。治疗后,治疗组IgA,IgG,IgM水平显著升高,与同组治疗前比较,差异有统计学意义(P<0.05);对照组IgA,IgG,IgM水平未见明显改善(P>0.05)。治疗后,治疗组CD_3^+,CD_4^+,CD_4^+/CD_8^+水平显著升高,与同组治疗前比较,差异有统计学意义(P<0.05);对照组CD_3^+,CD_4^+,CD_4^+/CD_8^+水平未见明显改善(P>0.05)。对照组总有效率为75.00%,治疗组为92.86%,经统计学分析,差异有统计学意义(P<0.05)。结论健脾益肺方辅助治疗哮喘缓解期肺脾气虚型可显著改善患儿的发作次数,提高机体免疫力,疗效显著,值得在临床上推广应用。

Objective To study the clinical efficacy of Jianpi Yifei Fang in the treatment of children in remission phase of asthma with lung-spleen deficiency pattern. Methods Children in remission phase of asthma with lung-spleen deficiency pattern from July 2012 to April 2016 in our hospital were randomly divided into therapy group （42 cases ） and control group （40 cases）. The control group was given Budesonide Formoterol Powder inhalant, while the therapy group was treated with Jianpi Yifei Fang based on the therapy of control group. The clinical therapeutic effects of two groups were observed after 3 months. Results After treatment, the asthma frequency of children in two groups was lower than that of before treatment with statistically significant differences （ P〈 0.05 ）. The level of IgA,IgG ,IgM ,CD3＋, CD4＋, CD4＋/CD8＋ in therapy group rose significantly （ P〈0.05 ）, there was no significant effect on these in control group （P〉0.05）. The total effective rate of therapy group （92.86%） was higher than that of the control group （75.00%） with significant differences （P 〈 0.05 ）. Conclusion Applied Jianpi Yifei Fang in the treatment of children in remission phase of asthma with lung-spleen deficiency pattern can increase physical immunity to reduce asthma frequency effectively, which is worthy of clinical promotion.