枳桔二陈汤辅助治疗儿童迁延性细菌性支气管炎44例临床观察

The clinical efficacy of Zhijie Erchen Tang in adjunctive treatment of 44 cases of protracted bacterial bronchitis in children

目的探讨枳桔二陈汤辅助治疗儿童迁延性细菌性支气管炎的临床疗效。方法将2013年12月至2016年6月于我院儿科确诊为儿童迁延性细菌性支气管炎的86例患儿随机分为对照组42例和治疗组44例,对照组采用阿莫西林克拉维酸钾静脉滴注治疗,治疗组在对照组治疗方法的基础上给予枳桔二陈汤口服,治疗14 d后统计2组的临床疗效及不良反应发生情况。结果 2组治疗前CD_3^+,CD_4^+,CD_4^+/CD_8^+免疫指标水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述指标均明显升高,与同组治疗前比较差异有统计学意义(P<0.05),且治疗组升高幅度大于对照组(P<0.05)。治疗组咳嗽、气喘、湿啰音、哮鸣音消失时间均较对照组短,经统计学分析,差异均有统计学意义(P<0.05)。对照组总有效率为73.81%,治疗组为93.19%,经统计学分析,差异有统计学意义(P<0.05)。对照组总不良反应发生率为26.19%,治疗组为9.91%,经统计学分析,差异有统计学意义(P<0.05)。结论枳桔二陈汤辅助治疗儿童迁延性细菌性支气管炎,可明显提高患儿的免疫功能,缩短病程,疗效显著。

Objective To explore the clinical efficacy of Zhiju Erchen Tang in adjunctive treatment of 44 cases of protracted bacterial bronchitis in children. Methods 84 cases of children with protracted bacterial bronchitis from December 2013 to June 2016 in our hospital were randomized into therapy group （44 cases） and control group （42 cases）. The control group was treated with intravenous drip of Amoxicillin Sodium and Clavulanate Potassium, while the therapy group was given Zhijie Erchen Tang by oral administration based on the therapy of control group. After treated for 14 days, the clinical effects and untoward effects of two groups were observed. Results Before treatment,there were no significant differences in the levels of CD3＋, CD4, CD4/CD8＋ of two groups （P〉0.05） ;They were much higher in two groups than that before treatment with significant differences （ P 〈 0.05 ） , and the increa- sing amplitude in therapy group was significantly greater than that in control group （ P〈0.05 ）. The disappearance time of asthma,cough,crackles and wheezing were shorter with statistically significant differences （P〈0.05）. The total effective rate in therapy group and control group was 93.19% and 73.81% respectively, differences were significant （P〈0.05）. The incidence rate of adverse reaction was 26.19% in control group,9.91% in therapy group with significant differences （P〈0.05）. Conclusion Zhijie Erchen Tang, as an adjunctive therapy, can treat children with protracted bacterial bronchitis effectively by enhancing immunity and promoting disease rehabilitation, which is worthy of clinical promotion.