实质浸润型肺炎支原体肺炎危险因素分析

Analysis of risk factors of invasive pneumonia

(1)目的寻找可能引起实质浸润型肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)的危险因素,为临床认识及治疗MPP提供参考。(2)方法收集我院儿科住院MPP患者的临床资料,运用二分类Logistics回归分析年龄、性别、发病至就诊时间、特应性体质、血浆白蛋白、入院前阿奇霉素使用情况等对不同影像类型MPP的影响,寻找引起实质浸润型MPP的独立危险因素。进入标准P≤0.05,退出标准为P≥0.1,P<0.1有统计学意义。(3)结果固定其他因素后年龄(P=0.013,OR=1.175)、发病至就诊时间(P=0.031,OR=0.871)、白蛋白(P=0.039,OR=0.908)、特应性体质(P=0.078,OR=0.420)是实质浸润型MPP的独立危险因素。(4)结论年龄大、发病至就诊时间短、白蛋白水平低、非特应质者更容易发生实质浸润型MPP。

Objective To explore possible risk factors for the occurrence of pulmonary parenchyreal infiltration in children with myeoplasma pneuoniae pneumonia（MPP）, and to provide some references for understanding and treatment of MPP.Methods The clinical data of the inpatients with MPP in our department of pediatrics,which included age,gender,time interval from onset to admission,ato py, serum albumin and pre-hospital .treatment with Azithromycin, were reviewed. Unconditional binary logistic regression analysis was used to find Independent risk factors for the development of parenchymal infiltrative MPP, the probability of variable entry and removal were 0.05 and 0.1 respectively. P values less than 0.1 was defined as statistically significant.Results The independent risk factors for the occurence of parenchymal infiltration in the children with MPP were age（ P =0.013, OR= 1.175）, time interval from onset to admission（ P =0.031 ,OR：0.871）,serum albumin（ P =0.039,OR=0.908） and atopy （ P =0.078,OR=0.420）.Conclusion The older age,shorter time interval from onset to admission,lower serum albumin level and no atopy are more likely to cause parenchymal infiltrative MPP.