参麦注射液治疗冠状动脉粥样硬化性心脏病心绞痛的临床效果

Clinical effect of Shenmai injection on coronary atherosclerotic heart disease with angina pectoris

目的探究参麦注射液治疗冠状动脉粥样硬化性心脏病（冠心病）心绞痛的临床效果。方法随机选取2015年6月至2016年6月武汉市普仁医院的80例冠心病心绞痛患者，根据住院号先后顺序分为观察组和对照组，各40例。2组所有患者均接受常规方案治疗（舒张血管、抗血小板聚集、抗凝、降脂、降压及降糖等），观察组同时接受参麦注射液静脉滴注治疗，均连续治疗14d。记录治疗前后患者的心电图变化、心绞痛发作频率并评价心绞痛治疗效果。记录治疗过程中的不良反应。结果治疗后，2组ST段下移、T波倒置幅度以及心绞痛发作频率均较治疗前明显降低[观察组：（1．17±0．20）mV比（2．55±0．91）mV、（0．05±0．03）mV比（0．26±0．08）mV、（1．4±0．4）O：／d比（5．5±1．3）次／d，对照组：（1．84±0．61）mV比（2．61±0．70）mV、（0．13±0．06）mV比（0．254,-0．08）mV、（2．1±0．8）次／d比（5．4±1．2）次／d]，且观察组明显低于对照组，差异均有统计学意义（均P〈0．05）。观察组总有效率明显高于对照组，差异有统计学意义[95．0％（38／40）比70．0％（28／40）]（P〈0．05）。观察组1例（2．5％）患者发生了轻度血压升高。结论冠心病心绞痛患者在常规治疗基础上加用参麦注射液，能够有效减少心绞痛的发作，改善心电图缺血表现，临床效果明显。

Objective To analyze the clinical effect of Shenmai injection on coronary atherosclerotic heart disease（CHD） with angina pectoris. Methods Eighty CHD patients with angina from June 2015 to June 2016 in Puren Hospital of Wuhan were divided into observation group and control group according to the order of admis- sion, with 40 cases in each group. Both groups had conventional treatments of vascular relaxing, antiplatelet aggre- gation, anticoagnlation, lipid lowering, antihypertension and glucose lowering; the observation group was treated with Shenmai injection for 14 d. Electrocardiographic findings, angina frequency, the therapeutic effect on angina and adverse reactions were analyzed. Results After treatment, amplitudes of ST-segment depression and T-wave inversion and the frequency of angina significantly decreased compared to those before treatment in both groups [ observation group ： （ 1.17 ± 0. 20 ） mV vs （ 2. 55 ± 0.91 ） mV, （ 0.05 ±0. 03 ） mV vs （ 0. 26 ± 0. 08 ） mV, （ 1.4 ±0. 4） times/d vs （5.5 ± 1.3）times/d; control group： （ 1.84 ±0. 61 ）mV vs （2. 61 ±0. 70） mV, （0. 13 ±0. 06）mV vs （ 0. 25 ±0. 08 ） mV, （ 2. 1 ± 0. 8 ） times/d vs （5.4 ± 1.2 ） times/d ] （ P 〈 0. 05 ） ; amplitudes of ST-segment depres- sion and T-wave inversion and the frequency of angina in observation group were significantly lower than those in control group （ P 〈 0. 05）. The total effective rate in observation group was significantly higher than that in control group[ 95.0% （ 38/40 ） vs 70.0% （ 28/40 ） ] （ P 〈 0. 05 ）. One patient （ 2. 5% ） in observation group had mild elevation of blood pressure. Conclusion Shenmai injection treating CHD with angina can reduce angina onset and relieve ischemia.