摘要
Kashin-Beck disease（KBD） is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen（CTX-Ⅱ）, pyridinoline（PYD）, and deoxypyridinoline（DPD） among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant（Z = 4.405, 3.653, and 3.724; P 〈 0.001）. The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD.
Kashin-Beck disease（KBD） is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen（CTX-Ⅱ）, pyridinoline（PYD）, and deoxypyridinoline（DPD） among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant（Z = 4.405, 3.653, and 3.724; P 〈 0.001）. The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD.
基金
supported by the Basic Research Projects of Science and Technology in Qinghai Province(2017-ZJ-770)
