黄秋葵胶囊对小鼠抗疲劳作用及机制研究

Effect on anti-fatigue of okra capsules for mice

目的:研究黄秋葵胶囊的抗疲劳作用及机制,为临床应用提供实验科学依据。方法:分别给小鼠灌胃给予黄秋葵胶囊内容物0.15、0.30、0.90 g/kg剂量,采用负重游泳实验方法观察黄秋葵胶囊的抗疲劳作用,并测定小鼠血清尿素氮、肝糖原、血乳酸含量,对黄秋葵胶囊抗疲劳作用机制进行初步探索。结果:负重游泳实验中,各剂量组小鼠负重游泳时间显著长于对照组(P<0.05);各剂量组小鼠血清尿素氮及血乳酸水平显著低于对照组(P<0.05)。结论:黄秋葵胶囊对小鼠具有显著的抗疲劳作用,且其机制与改善小鼠葡萄糖、蛋白质代谢分解、调节小鼠血清尿素氮及血乳酸水平有关。

Objective： To study the anti-fatigue effect of okra capsules and to provide experimental basis for clinical application. Methods： By mice＇s swimming test, measuring the serum urea nitrogen, lactic acid and the hepatic glycogen of mice after oral administration of different doses of okra capsules content （0.15, 0.30, 0.90 g/kg） and compared with the control group （treated with distilled water）. Result： Okra capsules could markedly improve mice＇s loaded-swimming time （P〈0.05）, reduce mice＇s serum lactic acid and urea nitrogen after strenuous exercise （P〈0.05）. Conclusion： The okra capsules could resist fatigue in mice.