抗实验性肝损伤中药复方的用药规律研究

Study on the Medication Rules of TCM Complex Formulas for Anti-experimental Liver Injury

目的:探究抗实验性肝损伤中药复方的用药规律。方法:以"实验性肝损伤""中药复方""保护作用"等为主题,检索中国期刊全文数据库、万方数据库、中文科技期刊数据库中与抗实验性肝损伤中药复方用药规律有关的相关文献,对纳入研究基本信息、中药分类、单味中药使用率与共现频率进行描述性分析;采用K-means聚类模型和SPSS Modeler中的Apriori算法对使用率排名前10位的药物进行聚类分析(聚类方与重要性)和关联分析。结果:检索到相关文献498篇,最终纳入有效文献70篇,涉及51种中药复方,包括111味中药。用药种类以清热药、补虚药、活血化瘀药为主;其中药物种类最多的是清热类,有34味;使用频次最高的是补虚药,有63次(使用率为25.82%);使用率最高的单味中药是柴胡(占总数的25.49%);共现频率最高的药对是柴胡-丹参。聚类分析结果共得到5个聚类方,即柴胡-丹参-当归-甘草、黄芪-当归-白花蛇舌草、茵陈-郁金-虎杖、柴胡-丹参-茵陈、五味子-甘草;重要性预测结果显示,在聚类方中五味子最重要、虎杖最不重要。关联分析共得到13条药组关联规则,但支持度与置信度均较低。结论:抗实验性肝损伤中药复方的组成以清热药、补虚药为主,但是用药配伍多样,相互关联度较低。

OBJECTIVE： To explore the medication rules of TCM complex formulas for anti-experimental liver injury. METH- ODS： Using ＂experimental liver injury TCM complex preparations protection effect＂ as themes, related literatures about medi- cation rules of TCM complex formulas for anti-experimental liver injury in CJFT, Wanfang database and VIP database were re- trieved, and general information, distribution, use frequency and co-occurrence frequency of single herbal medicine were descrip- tively analyzed. K-means clustering model and Apriori in SPSS Modeler were adopted for cluster analysis （clustering side and im- portance） and correlation analysis in medicines with top 10 use frequency. RESULTS： 498 related literatures were retrieved, and 70 valid literatures were involved totally, including 51 TCM complex formulas and 111 Chinese herbal medicines. It was mainly drug for clearing heat, restoring vital energy and blood circulation. Drugs for clearing heat were most widely used （34 varieties）, drugs for restoring vital energy showed the highest use frequency, with 63 times （25.82%） ; Prunella vulgaris had the highest frequency in single herbal medicines （accounting for 25.49% ） ; and P. vulgaris-Salvia miltiorrhiza had the highest co-occurrence frequency in drug pairs. 5 clustering sides were obtained in clustering analysis, which were P. vulgaris-S, miltiorrhiza-Angelica sinensis - Glycyr- rhiza uralensis, Astragalus membranaceus-A, sinensis-Hedyotis diffusa, Artemisia scoparia-Curcuma wenyujin-Plygonum cuspida- turn, P. vulgaris-S, miltiorrhiza-A, scoparia, Schisandra chinensis-G, uralensis. Importance prediction showed, S. chinensis was the most important and P. cuspidatum was the least important. 13 drug pair rules were obtained from correlation analysis, and both sup- port and confidence degrees were low. CONCLUSIONS： The TCM complex formulas for anti-experimental liver injury are mainly based on drugs for clearing heat and restoring vital energy, while the compatibility is varied, and correlation degree is relatively low.