异黄酮衍生物J39136对东莨菪碱致学习记忆障碍模型小鼠的影响

The effect of a novel isoflavonoid derivative J37941 on scopolamine-induced learning and memory deficits in mice

目的:本文旨在初步探讨具有乙、丁酰胆碱酯酶抑制活性的异黄酮衍生物J39136对小鼠东莨菪碱导致的学习记忆障碍的影响,为该化合物后续研究提供实验依据。方法:采用Morris水迷宫、跳台和避暗3个行为学实验,评价J39136不同剂量对小鼠认知和记忆的作用。结果:化合物J39136各给药组均有减少小鼠在避暗试验中的错误次数的趋势;J39136各剂量组均可显著延长小鼠的跳台潜伏期,减少小鼠的跳台错误次数,缩短小鼠在Morris水迷宫实验中的游泳潜伏期,具有一定的剂量依赖性。结论:化合物J39136能够改善东莨菪碱致学习记忆障碍,值得进行深入开发。

Objective： To investigate the ettect oI compouau J , acetylcholinesterase （ACHE） and butyrylcholinesterase （BuChE） inhibitory activities, on learning and memory impairment induced by scopolamine and to provide data basis for in-depth study of this compound. Methods： Step-down and step-through passive avoidance tests and Morris water maze test were used to evaluate the effect of J39136 on cognitive impairments in mice. Results： J39136administration reversed scopolamine-induced cognitive deficits in the passive avoidance tests, significantly increased step-down latency and reduced step-down error times. The escape latency during training in the Morris water maze test was reduced significantly as well. There is certain correlation between the effect and dose. Conclusion： J39136 can ameliorate cognitive deficits induced by scopolamine and it deserves further study.