可逆性胼胝体压部病变综合征的MRI表现

MRI Features of Reversible Splenial Lesion Syndrome

目的:分析可逆性胼胝体压部病变综合征(RESLES)的临床与磁共振成像(MRI)表现。方法:对14例RESLES患者的临床资料、MRI资料(病变的部位、形态、常规信号、DWI、ADC图及增强信号)及随访结果进行分析,总结RESLES的临床及MRI特征。结果:RESLES的临床诊断及病因包括病毒性脑炎(6例)、低钠血症(2例)、低血糖脑病(2例)、军团菌感染(1例)、癫痫(1例)、自身免疫性脑炎(1例)和剖宫产术后(1例);患者MRI表现为胼胝体压部孤立性类圆形病灶,T2WI及FLAIR呈稍高信号;DWI上呈明显高信号,相应表观扩散系数(ADC)图呈低信号,增强扫描未见强化;治疗后,1月内(平均21 d)复查MRI显示病灶消失。结论:RESLES可继发于多种临床疾病,MRI表现具有特征性可用于RESLES的诊断与鉴别。

Objective： To analyze the clinical manifestations and MRI features of reversible splenial lesion syndrome （RESLES）. Methods： The clinical data, MRI features （ lesion location, shape, con- ventional signal, DWI, ADC and enhanced signal） and follow-up results of 14 patients with RESLES were analyzed retrospectively. Summarizing clinical manifestations and MRI features of RESLES. Re- suits： Clinical diagnosis and etiology includes viral encephalitis （6 cases）, hyponatremia （2 cases）, hypoglycemic encephalopathy （2 cases）, Legionella infection （1 case）, epilepsy （1 case）, autoim- mune encephalitis （1 case） and cesarean section （1 case）. MRI findings were characterized as the round lesions of splenium of corpus callosum（SCC）. The lesions were slightly hyperintensity on T2WI, FLAIR and DWI, which showed hypointensity on the corresponding ADC images. No enhancement were found. The lesions were completely disappeared after one month （21 d in average） treatment. Conclusion： RESLES could be caused by many diseases. The MRI features are characteristic and play an important role in the diagnosis and differential diagnosis.