妊娠性高血压视网膜变化的临床研究（英文）

Clinical study of retinal changes in pregnancy induced hypertension

目的:研究妊娠性高血压(PIH)患者视网膜变化的患病率,视网膜变化与疾病严重程度的相关性。方法:横断面研究。共收集2014-12/2015-05妊娠性高血压患者100例。所有患者均行眼底检查。单眼或双眼眼底发生变化视为阳性。妊娠性高血压分级为轻度子痫前期(血压>140/90~160/90 mmHg),重度子痫前期(血压>160/90 mmHg)和子痫前期(重度子痫前期和抽搐)。结果:患者平均年龄为23.05(19~34)岁。妊娠期为28~41wk。其中62例初产妇以及38例经产妇。轻度子痫前期,重度子痫前期和子痫前期患者占比分别为62%,26%,12%。8例患者发生视网膜变化。观察得出:高血压性视网膜病变Ⅰ级(1%),Ⅱ级(0%),Ⅲ级(2%),Ⅳ级(2%),浆液性视网膜脱离(1%)和中心性浆液性脉络膜视网膜病变(2%)。视网膜变化与PIH严重程度呈正相关,有统计学意义(P=0.0001)。结论:8%的PIH患者视网膜发生变化,视网膜变化与PIH严重程度呈正相关。

AIM. To determine the prevalence of retinal changes in pregnancy induced hypertension （PIH） patients and to correlate between retinal changes and the severity ofdisease. METHODS： A cross-sectional observation study was conducted in 100 PIH patients over a period of 6mo （ Dec 2014-May 2015）. Fundus examination was done in all patients. Fundus changes in right or left or both eyes, was taken as positive, The PIH graded as mild pre- eclampsia （BP 〉 140/90 to 160/90 mmHg）, severe pre- eclampsia （BP〉160/90 mmHg） and eclampsia （severe pre- eclampsia and convulsions）. ~ RESULTS： Mean age was 23.05y （19- 34y）. Gestation period ranged from 28 to 41wk. Sixty-two were primi gravida and 38 were multigravida. 62%, 26%, 12% of patients had mild, severe pre- eclampsia, eclampsia respectively. Retinal changes were identified in 8 patients. Grade ], Grade U, Grade ]][, Grade IV hypertensive retinopathy （HTR）, serous retinal detachment （SRD） and central serous chorioretinopathy （CSCR） observed in 1%, 0%, 2%, 2%, 1% and 2% of patients respectively. There was a statistically significant positive association of retinal changes and severity of the PIH （ P= 0.0001 ）. CONCLUSION： Retinal changes were seen in 8% of patients with PIH and there is a positive correlation between retinal changes and severity of PIH.