隐源性机化性肺炎患者血清半乳凝素9水平变化及其临床意义研究

Change and Clinical Significance of Serum Galectin-9 Level in Patients with Cryptogenic Organizing Pneumonia

目的分析隐源性机化性肺炎(COP)患者血清半乳凝素9(Galectin-9)水平变化及其临床意义。方法选取2009年5月—2015年12月在连云港市第一人民医院呼吸内科住院治疗的社区获得性肺炎(CAP)患者26例(A组)和COP患者26例(B组),另选取同期连云港市第一人民医院体检健康者26例作为对照组。比较3组受试者血清Galectin-9水平,血清Galectin-9水平与COP患者COP面积比的相关性分析采用Pearson相关性分析,比较COP患者治疗前和治疗两周后血清Galectin-9水平和COP面积比。结果 A组和B组患者血清Galectin-9水平高于对照组,B组患者血清Galectin-9水平高于A组(P<0.05)。Pearson相关性分析结果显示,血清Galectin-9水平与COP患者COP面积比呈正相关(r=0.784,P<0.05)。COP患者治疗两周后血清Galectin-9水平和COP面积比均低于治疗前(P<0.05)。结论 COP患者血清Galectin-9水平明显升高,且血清Galectin-9水平可用于辅助诊断COP、评估患者病情严重程度及预后。

Objective To analyze the change and clinical significance of serum Galectin-9 level in patients with cryptogenic organizing pneumonia. Methods From May 2009 to December 2015 in the Department of Respiratory Medicine, the First People＇s Hospital of Lianyungang, 26 inpatients with community- acquired pneumonia were selected as A group, 26 inpatients with cryptogenic organizing pneumonia were selected as B group, meanwhile 26 healthy people admitted to this hospital for physical examination were selected as control group. Serum Galectin-9 level was compared among the three groups, and correlation between serum Galectin-9 level and cryptogenic organizing pneumonia area ratio was analyzed by Pearson correlation analysis ; serum Galectin-9 level and cryptogenic organizing pneumonia area of A group were compared before treatment and after 2 weeks of treatment. Results Serum Galectin-9 level of A group and B group was statistically significantly higher than that of control group, respectively, meanwhile serum Galectin-9 level of B group was statistically significantly higher than that of A group （P 〈 0.05 ）o Pearson correlation analysis results showed that, serum Galectin-9 level was positively correlated with cryptogenic organizing pneumonia area ratio in patients with eryptogenic organizing pneumonia （r = 0. 784, P 〈 0. 05）. After 2 weeks of treatment, serum Galectin-9 level and cryptogenic organizing pneumonia area ratio of A group were statistically significantly lower than those before treatment. Conclusion Serum Galectin-9 level is significantly elevated in patients with cryptogenic organizing pneumonia, can be used as assistant diagnostic indicator for cryptogenic organizing pneumonia, is helpful to evaluate the severity of illness and prognosis.