STAT4 rs7574865位点单核苷酸多态性与系统性红斑狼疮易感性Meta分析

Meta-analysis of the association between the STAT4 rs7574865 polymorphism and systemic lupus erythematosus

目的通过Meta分析探讨信号转导和转录激活因子4(STAT4)基因rs7574865位点单核苷酸多态性(SNP)与系统性红斑狼疮(SLE)易感性之间的关系。方法两名研究者分别检索Pub Med、Web of science、Scopus、中国知网和万方数据库,筛选出相关文献。用合并OR值和95%CI评价STAT4 rs7574865位点SNP与SLE易感性之间的关系。结果共纳入27篇研究,包含21 902例SLE患者和37 780例对照。Meta分析结果如下:等位基因模型(T vs G,OR=1.56,95%CI:1.49~1.63),纯合子模型(TT vs GG,OR=2.32,95%CI:2.08~2.58),杂合子模型(TG vs GG,OR=1.52,95%CI:1.41~1.64),显性遗传模型(TT/TG vs GG,OR=1.67,95%CI:1.55~1.79),隐性遗传模型(TT vs TG/GG,OR=1.83,95%CI:1.65~2.02)。按研究对象所在的地区进行亚组分析后显示,所有亚组中,rs7574865 SNP均与SLE易感性有关。结论 STAT4 rs7574865位点SNP与SLE的易感性有关,T等位基因的存在增加SLE的患病风险。

Objective To assess the association between STAT4 rs7574865 single nucleotide polymorphism and system- ic lupus erythematosus by a Meta-analysis. Methods Two authors searched PubMed, Web of science, Scopus, China National Knowledge Infrastructure （CNKI） and Wanfang databases to identify relevant studies, independently. Odds ra- tio （OR） with 95% confidence interval （CI） were calculated to assess the strength of the association between rs7574865 polymorphism and SLE risk. Results A total of 27 studies were eventually included in this meta-analysis, which contained 21 902 SLE cases and 37 780 controls. Pooled analyses showed significant association between STAT4 rs7574865 polymorphism and SLE risk using allelic model （T vs G, OR = 1.56, 95% CI： 1.49-1.63）, homozygote model （TT vs GG, OR=2.32, 95% CI： 2.08-2.58）, heterozygote model （TG vs GG, OR=1.52, 95% CI： 1.41- 1.64）, dominant model （TT/TG vs GG, OR = 1.67, 95% CI： 1.55-1.79） and recessive model （TT vs TG/GG, OR = 1.83, 95% CI： 1.65-2.02）. In the subgroup analysis by region, evidences also showed significant association between rs7574865 polymorphism and SLE risk in all regions. Conclusion STAT4 rs7574865 G 〉 T polymorphism correlate with an increased risk of SLE and the T allele may be a risk factor.