老年精神分裂症应用阿立哌唑与喹硫平治疗的疗效比较

Comparison of the efficacy of aripiprazole and quetiapine in treatment of elderly patients with schizophrenia

目的观察比较喹硫平、阿哌利唑2种药物治疗老年精神分裂症的临床效果。方法选取医院收治的老年精神分裂症患者70例,随机分为A、B 2组,每组35例。A组给予喹硫平治疗,B组给予阿立哌唑治疗,观察比较2组患者的治疗效果及相关临床指标(催乳素、BMI、血糖)。结果 A组总有效率为91.43%,B组总有效率为94.29%,2组比较差异无统计学意义(P>0.05)。治疗前后B组所有指标、A组BMI指数比较,差异均无统计学意义(P>0.05);A组催乳素、血糖则在治疗前后出现显著变化(P<0.05)。说明B组在安全性上优于A组。结论在老年精神分裂症的治疗中,喹硫平与阿立哌唑疗效相近,但在安全性上阿立哌唑优于喹硫平。

Objective To compare the efficacy of quetiapine and apelizole in treatment of elderly patients with schizo- phrenia. Methods Seventy elderly patients with schizophrenia were randomly divided into two groups ： the control group and the study group with 35 cases of each. Group A was given quetiapine treatment, group B was treated with aripiprazole ; the treat- ment of 2 groups of patients and the relevant clinical indicators （ prolactin, BMI, blood glucose ） were observed and compared. Results The total effective rate, in group A was 94.29% , the control group was 91.43%. The statistical difference between the two groups is not significant （P 〉 0.05 ） ;There were no significant differences in the BMI index between the two groups be- fore and after treatment （P 〉 0.05 ）. The levels of prolactin and blood glucose in group A were significantly changed before and after treatment （P 〈 0.05 ） indicating that group B is superior to group A in safety. Conclusion In the treatment of elderly schizophrenia, quetiapine and aripiprazole have similar efficacy. But aripiprazole is superior to quetiapine in the perspective of safety.