宫腔镜术后应用戊酸雌二醇治疗宫腔粘连临床效果观察

Clinical analysis of treatment of intrauterine adhesions with estradiol valerate

目的观察实施宫腔镜手术后应用戊酸雌二醇治疗宫腔粘连的临床效果。方法选取医院实施宫腔镜手术后应用戊酸雌二醇治疗的患者69例为观察组,以同期实施宫腔镜术后未应用戊酸雌二醇治疗的患者69例为对照组,对2组进行定期随访,比较分析治疗效果、子宫内膜厚度、受孕情况及不良反应情况。结果观察组治疗有效率为94.2%,高于对照组的59.4%;观察组患者子宫内膜平均厚度为(9.7±2.7)mm,大于对照组的(4.2±2.3)mm;观察组术后1年成功受孕37例,多于对照组的19例,各项数据组间比较差异均有统计学意义(P<0.05或P<0.01)。观察组69例患者中,有7例服药后有恶心现象,比较轻微,患者可耐受,未见严重肝肾功能异常患者。结论宫腔镜术后应用戊酸雌二醇治疗宫腔粘连效果确切,有助于子宫内膜恢复和受孕,不良反应较少,可进行临床推广。

Objective To observe the clinical effect of using estradiol valerate in the treatment of intrauterine adhe- sions after hysteroscopy. Methods 69 cases in our hospital after hysteroscopic surgery application of estradiol valerate therapy patients formed the study group, and 69 cases with implementation of hysteroscopic surgery while without application of estradi- ol valerate in the same period formed control group. The two groups were followed up regularly to analyze the therapeutic effect, endometrial thickness, adverse reaction and conception. Results The effective rate was 94.2% in the observation group higher than that of 59.4% in the control group. The average thickness of the endometrium in the observation group was （9.7 ± 2.7 ） ram,which was thicker than that in the control group （4.2±2.3 ） ram;There were 37 cases of successful conception greater than that of 19 cases in the control group. The difference between the data groups was statistically significant （P 〈 0. 05 or P 〈 0. O1 ）. The difference of the data between the groups were statistically significant, among 69 patients in study group, there were 7 cases of nausea after taking drugs, relatively mild and tolerated, and no serious liver and kidney dysfunction in patients were found. Conclusion The effect of the application of estradiol valerate in the treatment of intrauterine adhesions after hystero- scopic surgery is significant, which is helpful for endometrial recovery and conception with fewer side effects and worthy of clinical promotion.