疏肝健脾安神方对功能性消化不良伴焦虑抑郁患者胃肠激素的影响

The Effect of Soothing Liver and Invigorating Spleen Calming Therapy on Gastrointestinal Hormones in Patients With Functional Dyspepsia Accompanied With Anxiety and Depression

目的观察疏肝健脾安神方对功能性消化不良(FD)伴焦虑抑郁患者的治疗效果和血浆MTL及CCK的影响。方法选取119例FD伴焦虑抑郁的患者作为研究对象,将其随机分为治疗组和对照组,两组患者分别给予疏肝健脾安神方和西药治疗,均用药4周。观察两组患者临床疗效、HAMA和HAMD评分以及血浆MTL和CCK含量的变化情况。结果治疗组总有效率(96.67%)优于对照组(82.5%),差异具有统计学意义(P<0.05)。治疗后,两组的MTL水平均升高(P<0.05),CCK水平、HAMA及HAMD评分均降低(P<0.05)。结论疏肝健脾安神方治疗FD伴焦虑、抑郁疗效显著,能改善患者的抑郁状态,调节MTL和CCK的分泌,增加胃肠动力、促进胃排空。

Objective To observe the effect of soothing liver and invigorating spleen calming therapy on the treatment of functional dyspepsia （FD） accompanied with anxiety and depression and the effects of plasma MTL and CCK. Methods 119 patients with FD with anxiety and depression were randomly divided into treatment group and control group. They were treated with soothing liver and invigorating spleen calming therapy and western medicine respectively. The clinical efficacy, HAMA and HAMD scores and changes of plasma MTL and CCK contents were observed. Results The total effective rate （96.67%） in the treatment group was better than that in the control group （82.5%）, the difference was statistically significant （P〈0.05）. The levels of MTK, HAMA and HAMD were significantly decreased （P 〈0.05） in two groups after treatment （P 〈 0.05）. Conclusion Soothing liver and invigorating spleen calming therapy has remarkable curative effect on FD accompanied with anxiety and depression. It can obviously improve the depression state, regulate the secretion of MTL and CCK, increase the gastrointestinal motility and promote the gastric emptying.