超敏C反应蛋白对经皮冠状动脉介入治疗患者预后的预测

Prognostic Value of High Sensitivity C Reactive Protein in Patients Undergoing Percutaneous Coronary Intervention

目的探讨超敏C反应蛋白预测经皮冠状动脉介入治疗预后的应用价值。方法抽取我院2015年4月—2016年8月收治的行经皮冠状动脉介入术治疗的不稳定型心绞痛患者68例为研究对象,术前对所有患者进行超敏C反应蛋白(hs-CRP)检测,将30例hs-CRP正常者作为甲组,38例hs-CRP升高者作为乙组,术后随访半年,观察两组远期疗效。结果甲组糖尿病率30%(9例)及高血压率20%(6例),均比乙组糖尿病率55.26%(21例)及高血压率50%(19例)低(P<0.05);甲组TC、TG、LDL-C、hs-CRP值均低于乙组(P<0.05),两组HDL-C对比,差异无统计学意义(P>0.05);甲组术后心血管事件发生率10.00%,低于乙组31.58%(P<0.05)。结论超敏C反应蛋白水平升高会增加经皮冠状动脉介入术后心血管事件发生风险,加强超敏C反应蛋白检测有助于预后预测。

Objective To investigate the value of high sensitivity C reactive protein in predicting prognosis of percutaneous coronary intervention. Methods 68 patients with unstable angina pectoris treated by percutaneous coronary intervention from April 2015 to August 2016 in our hospital were selected as the subjects, preoperative hypersensitivity C reactive protein （hs-CRP） test was performed on all patients, 30 cases of normal subjects as a hs-CRP, 38 patients with elevated hs-CRP were served as group B, the patients were followed up for six months, the long-term effects of the two groups were observed. Results The diabetes rate was 30% （9 cases） and hypertension was 20% （6 cases）, compared with group B, the rate of diabetes was 55.26% （21 cases） and the rate of hypertension was 50% （19 cases） （P〈0.05）; The TC, TG, LDL-C, hs-CRP were lower than that of group B （P〈0.05）, The difference of HDL-C between the two groups was not statistically significant （P〉0.05）; The postoperative incidence of cardiovascular events 10%, lower than group B, 31.58% （P〈0.05）. Conclusion Elevated levels of hypersensitive C reactive protein may increase the risk of cardiovascular events after percutaneous coronary intervention, enhanced detection of hypersensitive C reactive protein may help predict prognosis.