克拉霉素联合甲硝唑及叶酸治疗萎缩性胃炎临床分析

Clinical Analysis of Clarithromycin Combined With Metronidazole and Folic Acid in the Treatment of Atrophic Gastritis

目的对克拉霉素联合甲硝唑及叶酸应用于萎缩性胃炎患者中的临床效果进行分析研究。方法选取122例2015年4月—2017年1月接受治疗的萎缩性胃炎患者,并1∶1随机分为参照组(给予阿莫西林、甲硝唑及叶酸联合治疗)和实验组(给予克拉霉素联合甲硝唑及叶酸治疗)各61例,对两种不同方案的效果进行对照研究。结果就治疗总有效率而言,实验组患者高于参照组(93.44%vs.72.13%);就不良反应发生率而言,实验组患者低于参照组(8.20%vs.29.51%),P<0.05,组间差异具有统计学意义。结论克拉霉素联合甲硝唑及叶酸应用于萎缩性胃炎患者中的临床效果十分理想。

Objective To investigate and analyze the clinical effect of clarithromycin combined with metronidazole and folic acid in patients with atrophic gastritis. Methods 122 patients with atrophic gastritis treated in our hospital from April 2015 to January 2017 were randomly divided into control group （amoxicillin, metronidazole and folic acidcombination） and experimental group （clarithromyein combined with metronidazole and folic acid） with ratio 1 ： 1, 61 cases in each group, and the effect of two different treatment was compared. Results The total effective rate of experimental group was significantly higher than that of control group （93.44% w72.13%）; incidence of adverse reactions in experimental group was significantly lower than that ofcontrol group （8.20% vs. 29.51%）, the difference between two groups statistically significant, P〈0.05. Conclusion The clinical effect of clarithromycin combined with metronidazole and folic acid applied to patients with atrophic gastritis is satisfactory.