春季肌内注射维生素D_2注射液对高龄老人血清25-羟基维生素D和甲状旁腺激素水平的影响

Influence of intramuscular vitamin D_2 injection in spring on serum 25-hydroxyvitamin D and parathyroid hormone in very elderly persons

目的研究在春季肌内注射(肌注)维生素D_2注射液对高龄老人血清25-羟基维生素D[25-(OH)D]和甲状旁腺激素(PTH)水平的影响。方法于2016年1月纳入45例年龄≥80岁的老人,随机分成两组,治疗组22例,对照组23例。治疗组在坚持晒太阳的基础上,予维生素D_2注射液60万单位,肌注,每月1次,连续3次;对照组仅坚持晒太阳。检测两组治疗前、治疗后每个月血清25-(OH)D、PTH、钙、磷等指标,并记录不良反应发生情况。结果治疗组完成20例,对照组完成19例。治疗组治疗第1个月起老人血清25-(OH)D水平即高于对照组,治疗第2~8个月治疗组25-(OH)D水平也高于对照组,差异均有显著意义(P<0.05)。两组血清PTH、钙和磷水平比较,差异均无显著意义(P>0.05)。未见严重不良反应发生。结论在春季连续肌注维生素D_2注射液3次,有助于迅速提高和维持高龄老人血清25-(OH)D水平,值得临床应用。

AIM To evaluate the influence of intramuscular vitamin D2 injection in spring on serum 25- hydroxyvitamin D and parathyroid hormone in very elderly persons. METHODS A total of 45 persons aged 80 and over were randomized into either treatment group （in addition to sunbath, 600 000 IU of vitamin D2 was intramuscularly given, monthly from January to March in 2016） or the control group （sunbath only）. The serumlevels of 25- hydroxyvitamin D, parathyroid hormone, calcium and phosphorus and so on were detected from January to September. The adverse drug reactions were observed and recorded during the study. RESULTS There were 20 cases completed the trial in the treatment group and 19 eases in the control group. The serum concentrations of 25-hydroxyvitamin D in the treatment group were significantly higher than those in the control group from February to September （all P 〈 0.05）. There were no significant difference in serum parathyroid hormone, calcium and phosphorus between two groups during nine months （all P 〉 0.05）. No severe adverse drug reactions occurred during the treatment. CONCLUSION Consecutive administration of vitamin D2 injection in spring is helpful for rapidly increasing and maintaining serum 25- hydroxyvitamin D level in very elderly persons.