慢性牙周炎中肿瘤坏死因子ɑ对骨髓间充质干细胞成骨分化的调控作用

Tumor necrosis factor-α regulates the osteogenic differentiation of bone marrow mesenchymal stem cells in chronic periodontitis

骨髓间充质干细胞(BMSCs)在重构牙周组织结构和功能、促进牙周炎好转乃至愈合方面发挥重要作用,因此BMSCs的特性尤其是其成骨分化的调控机制是目前的研究热点。肿瘤坏死因子α(TNF-α)是牙周组织炎症微环境中的主要促炎因子,与BMSCs的成骨分化密切相关。探究TNF-α调控BMSCs成骨分化的机制有助于明确牙周炎的发病机制,寻找牙周疾病新的治疗靶点,改善牙周炎的治疗效果。本文将针对TNF-α在牙周炎发生发展过程中发挥的重要作用尤其是调控BMSCs成骨分化的可能机制作一综述。

Bone marrow mesenchymal stem cells （BMSCs） and ideal adult stem cells for alveolar bone regeneration consi- derably help restore the structure and function of the periodontium and promote the healing of periodontal disease. Thus, BMSC features, especially the mechanism of osteogenic differentiation, has recently become a research hotspot. Tumor necrosis factor-ɑ （TNF-ɑ）, which is the main factor in the periodontal inflammatory microenvironment, is directly related to the osteogenic differentiation of BMSCs. Exploring the TNF-ɑ-regulated differentiation mechanism of BMSCs aids in the search for new treatment targets. Such investigation also promotes the development of stem cell therapy for periodontal diseases. This article aims to describe the potential of TNF-ɑ in regulating the osteogenic differentiation of stem cells.