尿总蛋白尿肌酐比值参考范围探讨

Discussion of reference ranges of urine protein-creatinine ratio

目的建立适合成都市第二人民医院检验科所用检测系统的尿总蛋白肌酐比值参考范围。方法使用该科室检测系统对550例健康者进行尿总蛋白和尿肌酐测定,并计算尿总蛋白尿肌酐比值。使用SPSS统计软件对数据进行分析,建立参考范围。结果尿总蛋白肌酐比值呈偏态分布,性别之间差异无统计学意义(P>0.05)。60岁以下组和60岁及以上组差异有统计学意义(P<0.05),分别取第95%百分位数为参考值区间的上限,得出尿总蛋白尿肌酐比值参考范围,60岁以下为0~111mg/g,60岁及以上为0~164mg/g。结论尿总蛋白肌酐比值可作为评估肾脏损伤的指标。

Objective To establish the reference ranges of urine protein-creatinine ratio for the laboratory.Methods Urine samples were randomly collected from 550 inpatients and were analyzed.The urinary total protein and urine creatinine were tested.In addition,the urine protein-creatinine ratio and the normal reference ranges were calculated by SPSS.Results The urine protein-creatinine ratio was positively skew distribution.And the difference of urine protein-creatinine ratios between male and female had no statistical significances （P〉0.05）.There was significant difference between people aged above 60 years people and aged less than 60 years （P〈0.05）.So the 95% percentile of urine protein-creatinine ratio was regarded as the upper limit of reference ranges of the two groups.And the range of people aged above 60 years was 0-111 mg/g and which of the people aged less than 60 years was 0-164 mg/g.Conclusion The urine protein-creatinine ratio is a simple and convenient indictor in evaluating the condition of kidney injury.