Graves病相关性肾损害的研究

Study of renal damage associated with Graves disease

目的探讨Graves病与肾损害的关系。方法收集127例Graves病患者,按照有无肾损害分为损害组(n=27)和未损害组(n=100)。采用西门子ADVIA2400全自动生化分析仪检测血清三碘甲状腺原氨酸(FT3)、游离甲状腺素(TF4)、促甲状腺素(TSH)、甲状腺球蛋白抗体(TGAb)和甲状腺过氧化酶抗体(TPOAb),采用西门子CENTAUR XP化学发光免疫分析仪检测促甲状腺受体抗体(TRAb)。结果肾损害组与未损害组的FT3、FT4、TGAb、TPOAb水平差异无统计学意义(P>0.05),TRAb水平差异有统计学意义(P<0.05);年龄、性别与肾损害率无关(P>0.05);血清FT3、FT4、TGAb、TPOAb水平与肾损害率无关(P>0.05);血清TRAb越高,肾损害率越高,差异具有统计学意义(P<0.05)。结论 Graves病相关肾损害与免疫因素有关;TRAb可能参与了Graves病肾损害的进程。

Objective To study the relationship between Graves disease and renal damage.Methods A total of 127 patients with Graves disease were collected.According whether the patients had renal damage,they were divided into the renal damage group（n=27） and non-damage group （n=100）.SIEMENS ADVIA2400 automatic biochemical analyzer was applied to detect the levels of triiodothyronine （FT3）,free thyroxine （FT4）,thyrotropin （TSH）,thyroglobulin antibody （TGAb） and thyroid peroxidase antibody （TPOAb）.SIEMENS automatic chemiluminescence immunoassay analyzer were applied to detect levels of thyrotropin receptor antibody（TRAb）.Results There were no significant differences between the levels of FT3,FT4,TGAb and TPOAb in renal damage group and non-damage group （P〉0.05）,but the level of TRAb in the damage group was significantly higher than that in the non-damage group（P〈0.05）.Age and sex had no correlation with renal damage （P〉0.05）.The levels of FT3,FT4,TGAb and TPOAb were not related with renal damage （P〉0.05）.The higher the level of TRAb,the more likely renal damaged （P〈0.05）.Conclusion Immune factors are relevant to Graves disease related renal damage.TRAb devotes to the course of Graves disease related renal damage.