氟哌噻吨美利曲辛片联合埃索美拉唑肠溶片对于慢性胃炎并发GERD患者临床效果研究

Clinical effect of flupentixol melitracen sheet combined with esomeprazole magnesium enteric-coated tablets on treatment of patients with chronic gastritis complicated with GERD

目的研究氟哌噻吨美利曲辛片(又称黛力新)联合埃索美拉唑镁肠溶片(又称耐信)治疗慢性胃炎并发胃食管反流病(GERD)的临床效果,为该类胃肠疾病患者的治疗提供依据。方法选取2014年6月至2015年12月治疗的166例慢性胃炎并发GERD患者进行了研究,随机分为两组,每组83例。对照组单独给与耐信,观察组在耐信治疗基础上加用黛力新,两组治疗时间均为6周。比较两组患者治疗前后GERD量表评分结果、治疗前后焦虑/抑郁评分变化,以及治疗前后胃镜检查病变分级变化,最后比较两组治疗方案的总有效率。结果两组患者治疗后1个月和2个月后的胃食管反流病量表评分均明显低于治疗前,且治疗后两组比较中,观察组两个时间点的评分均明显低于对照组,两组间比较差异有统计学意义(P<0.05);两组患者治疗后1个月和2个月后的抑郁量表、焦虑量表和汉密顿抑郁量表评分均明显低于治疗前,且治疗后两组比较中,观察组2个时间点的评分均明显低于同期对照组的评分,两组间比较差异有统计学意义(P<0.05)。在胃镜检查分级评分比较中,与治疗前比较,两组患者1~4级病变所占比例明显减少,在治疗后病变程度比较中,观察组1~4级病变所占比例明显低于对照组,两组比较差异有统计学意义(P<0.05);观察组临床总有效率为95.2%,明显高于对照组(75.9%),两组间比较差异有统计学意义(P<0.05)。结论黛力新联合耐信治疗慢性胃炎并发GERD临床效果显著,患者的胃食管病变明显减轻,临床症状得到显著的控制,且患者的心理状态改善更优异,值得推广使用。

Objective To study the effect of flupentixol melitracen sheet（Deanxit） and esomeprazole magnesium enteric-coated tablets（Nexium） on treatment of patients with chronic gastritis complicated with gastroesophageal reflux disease （GERD）,for providing reference for treatment of gastrointestinal diseases.Methods A total of 166 patients from June 2014 to December 2015 with chronic gastritis complicated by GERD were enrolled in our hospital,which were randomly divided into two groups,each group had 83 cases.The patients in control group was given esomeprazole alone,and the patients in observation group was given esomeprazole and flupentixol melitracen tablets,the treatment period was 6 weeks.In addition,the GERD scale scores,the anxiety/depression scores,endoscopy lesion grade changes and clinical effect was compared before and after treatment.Results The GERD scale score in the first month and second month was significantly lower than before in two groups （P〈0.05）,the score in observation group was significantly lower than the control （P〈0.05）.The anxiety and depression scores including SAS,SDS and HAMD were significantly lower than before treatment in two groups,the score in observation group was significantly lower than the control group （P〈0.05）.In grading endoscopy,when compared with before,patients in grade 1-4 lesions were significantly reduced.The proportion of the patients with grade 1-4 lesions in observation group was significantly lower than control group （P〈0.05）.The total clinical efficiency in observation group was up to 95.2%,which was significantly higher than that in control group （75.9%） （P〈0.05）.Conclusion The clinical effect of Deanxit with Nexium on patients with chronic gastritis and GERD is obvious,and the patients′ mental state is more excellent,which is worthy to be generalized.