腮腺黏液表皮样癌与人乳头瘤病毒感染的相关性研究

Research on the relationship between mucoepidermoid carcinoma and human papillomavirus infection

目的探讨腮腺黏液表皮样癌的发生与人乳头瘤病毒(human papillomavirus,HPV)感染的相关性。方法应用巢式PCR技术,采用通用引物对51例腮腺黏液表皮样癌组织中的HPV DNA进行检测,9例慢性腮腺炎组织作为对照组。结果 51例腮腺黏液表皮样癌组织中37例可检测甘HPV DNA,阳性率为72.5%,慢性腮腺炎组织中HPV DNA阳性率为22.2%(2/9),两者差异有统计学意义(x^2=8.517,P=0.004)。结论腮腺黏液表皮样癌的发生可能与HPV惑染有关。

OBJECTIVE To find out the relationship between mucoepidermoid carcinoma and Human papillomavirus （HPV） infection. METHODS Nested polymerase chain reaction （Nested PCR） was adapted to detect HPV DNA from 51 tissues of mucoepidermoid carcinoma using consensus primers, 9 tissues of chronic parotitis were as control. RESULTS HPV DNA was detected in 37 of total 51 mucoepidermoid carcinoma tissues, the detection rate was up to 72.5%, comparatively, it was 22.2% （2 of 9） in chronic parotitis tissues. The HPV DNA detection rate of mucoepidermoid carcinoma tissues was statistically higher than that of chronic parotitis tissues （Z2=8.517, P=0.004）. CONCLUSION The results suggested that the HPV infection may cause mucoepidermoid carcinoma.