不同类型肥胖与骨质疏松症的研究

Study on the different types of obesity and osteoporosis

目的旨在分析肥胖与骨质疏松症的关系,为肥胖与骨质疏松症的防治提供切实可信的数据。方法选取2014年1月至2015年1月在哈尔滨医科大学附属第二医院体检中心进行体检人员1192例,测定甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹血糖(FBG)的值。采用双能X线骨密度扫描双侧股骨及腰椎进行骨密度检测,根据骨密度T值分为骨量正常组、骨量减少组和骨质疏松组并结合身高、体重、血压、腰围等分为全身性肥胖、复合型肥胖、中心性肥胖,使用t检验和χ~2检验各组间有无统计学差异,对检测结果进行分析。结果在男性群体中50~59岁年龄组骨质疏松检出率明显升高(12.06%),80~89岁组达到最高(16.67%);女性群体中随年龄增长骨质疏松检出率有所增加,而70~79岁组骨质疏松的检出率最高为54.55%。在骨量正常组、骨量减少组及骨质疏松组3组中空腹血糖、甘油三酯和低密度脂蛋白胆固醇组间比较有差异,且具有统计学意义(P<0.05)。合并一种代谢异常与骨质疏松的研究中,高血糖、血脂异常合并骨质疏松组间比较差异显著,有统计学意义;两种代谢异常合并骨质疏松组间比较差异显著,有统计学意义(P<0.05)。复合型肥胖、中心性肥胖合并骨质疏松组间比较差异显著,有统计学意义(P<0.05)。结论不同类型的肥胖与骨质疏松的关系并不一致。

Objective To analyze the relationship between obesity and osteoporosis,and to provide reliable data for the prevention and treatment of obesity and osteoporosis.MethodsA total of 1192 people for health screening in Harbin Medical University Affiliated Second Hospital from Jan 2014 to Jan 2015 were enrolled.Triglyceride,total cholesterol,lowdensity lipoprotein,high density lipoprotein,and fasting blood glucose（FBG）were measured.Bone mineral density（BMD）of the femurs and lumbar vertebrae was determined using dual energy X-ray absorptiometry.People were divided to normal bone mass group,bone loss group,and osteoporosis group,according to the BMDT score,and to general obesity,combined obesity,and central obesity,according to height,weight,blood pressure.The results were analyzed using t-test and x2 test for statistical difference among the groups.ResultsOsteoporosis detection rate of the 50-59 age group in the male population increased significantly（12.06%）,and it reached to the highest in the 80-89 age group（16.67%）.In the female group,the detection rate in the 70-79years old group was the highest（54.55%）.There were significant differences in fasting blood glucose,triglyceride,and lowdensity lipoprotein cholesterol among the normal bone mass group,bone loss group,and osteoporosis group,and the difference was statistically significant（P〈0.05）.In the study of one metabolic abnormality with osteoporosis,there was statistically different between high blood sugar and high blood fat with osteoporosis group（P〈0.05）.In two metabolic abnormalities associated with osteoporosis group the differences between the two group were statistical significance（P〈0.05）.The difference was statistically significant between complex obesity and central obesity with osteoporosis group（P〈0.05）.Conclusion The relationship between different types of obesity and osteoporosis is not consistent.