绝经后不同骨关节退行性疾病与骨质疏松程度的相关性研究

The correlation between different degenerative bone and joint diseases and osteoporosis in postmenopausal women

目的探讨绝经后女性不同骨关节退行性疾病的临床特点及与骨密度的关系,为防治绝经后骨关节退行性疾病提供依据。方法选取2013年9月至2016年3月在我院收治的959例绝经后女性患者,取腰椎和股骨颈处的最大的骨密度值及T值作为研究对象,按不同骨关节退行性疾病分为脆性骨折组、腰椎退行性病变组、膝骨关节炎组及无明显骨关节疾病对照组。采用SPSS 19.0软件进行统计学分析。结果 (1)各组间腰椎BMD值及T值的差异具有统计学意义(P<0.05),其中腰椎退行性病变组患者的腰椎骨密度值和T值均比其他3组明显减低(P<0.05),膝骨关节炎组骨密度值和T值均高于其他3组(P<0.05);(2)各组间股骨颈BMD值及T值的差异具有统计学意义(P<0.05),其中脆性骨折组患者的股骨颈骨密度值和T值均比其他3组明显减低(P<0.05),膝骨关节炎组骨密度值和T值均高于其他3组(P<0.05)。结论在绝经后女性患者中,脆性骨折与骨质疏松的关系最为密切,而其他骨关节疾病也在不同程度上与骨质疏松程度存在显著相关性,在治疗骨关节疾病的同时也要重视骨质疏松症的防治。

Objective To explore the clinical characteristics of different bone and joint degenerative diseases in postmenopausal women,and its relationship with bone mineral density（ BMD）,which may provide the basis for prevention and treatment of postmenopausal bone and joint degenerative disease. Methods From September 2013 to March 2016,959 cases of postmenopausal women were chosen in our hospital. BMD and T value of the lumbar spine and femoral neck were the research objects. According to the different bone and joint degenerative diseases,they were divided into fragility fracture group,lumbar degenerative disease group,knee osteoarthritis group,and no obvious joint disease groups. SPSS 19. 0 software was used for the statistical analysis.Results（1） Lumbar BMD and T values were different with statistical significance among groups（ P 〈 0. 05）,and they were lowest in the lumbar degenerative diseases patients comparing to the other 3 groups（ P 〈 0. 05）,while they were the highest in the knee osteoarthritis group comparing to the other 3 groups（ P 〈 0. 05）.（2） Femoral neck BMD and T values were statistically different among groups（ P 〈 0. 05）,and they were the lowest in the fragility fracture group comparing to the other 3 groups（ P 〈0. 05）,while they were the highest in the knee osteoarthritis group comparing to the other 3 groups（ P 〈 0. 05）. Conclusion The fragility fracture is mostly related to osteoporosis in postmenopausal women,while other bone and joint diseases are significant correlated to osteoporosis in different extent and degree. In the treatment of the bone and joint diseases,we should pay attention to the prevention of osteoporosis at the same time.