骨微损伤形成与修复机制的研究进展

Research progress on the development and repair mechanisms of bone microdamage

骨微损伤是在光学显微镜下能够观察到的骨基质损害,骨微损伤的产生、发展与疲劳载荷有关,骨微损伤能够启动骨重建来进行修复,但不同微损伤类型对骨重建的影响不同。骨微损伤有五种类型,目前研究多集中在线性微裂纹与弥散性微损伤,它们具有完全不同的形态特征和修复方式。本文通过对骨微损伤的分类、检测方法、形成及修复机制进行综述,深入研究神经肽对骨重建的作用,旨在进一步探讨骨微损伤的修复机制,为骨质疏松性骨折的防治奠定基础。

Bone microdamage is generally defined as matrix failure detectable by light microscope. The accumulation and development of bone microdamage is associated with fatigue loading. Bone remodeling can be activated to target the repair of bone microdamage. But different types of bone microdamage have different effects on bone remodeling. There are five types of bone microdamage. Most research are focused on the linear microcrack and diffuse microdamage,and they have completely different morphological characters and repair mechanisms. This paper reviews the classification,measurement,development and repair mechanisms of bone microdamage,evaluate the role of neuropeptide on bone remodeling,with the aim of further exploring the possible repair mechanisms of bone microdamage and laying the foundation for the prevention of osteoporotic fracture.