广州市正常儿童血清维生素B1和B2参考区间调查

Investigation on the normal reference ranges for serum vitamin B1 and B2 of healthy children in Guangzhou

目的建立广州市健康儿童血清维生素B1和B2的参考区间,为临床精准判断儿童维生素B1、B2状态提供循证医学证据。方法应用LK3000V维生素检测仪对广州市1 442名健康儿童(男性809例,女性633例)的血清维生素B1和B2进行检测,对结果进行统计分析。结果 1)10岁以内的10个年龄组、10~17岁和>17岁组血清维生素B1和B2水平性别差异均无统计学意义(P>0.05)。2)血清维生素B1水平[中位数(P2.5,P97.5)]为:0~3岁组为41.9(45.6,88.1nmol/L,单位下同),3~5岁组为65.5(45.6,98.4),5~17岁组为72.9(46.3,105.8),>17岁组为80.6(46.7,115.9)。血清维生素B2的水平为:0~5岁组为285.6(197.3,376.2μg/L,下同),5~17岁组为297.9(208,387.4),>17岁组为308.2(280.6,394.7)。3)年龄与血清维生素B1和B2相关系数分别是0.345和0.226(P<0.05)。结论广州市正常儿童血清维生素B1参考区间无年龄差异,而血清维生素B2参考区间以5岁为界分别建立。

Objective To establish the normal reference range for serum vitamin B1 and B2 of healthy children in Guangzhou and to porovide evidence for clinical accurate judgment of vitamin B1 and B2 status in children. Methods Serum vitamin B1 and B2 of 1 442 healthy children （809 males,633 females）living in Guangzhou were examined by LK3000V Vitamin Analyzer. Then the data were analyzed with statistical methods. Results 1）There was no statistical difference between boys and girls for levels of serum vitamin B1 and B2 between every group defined by age within ten years old（P〈0.05）. 2）The levels of serum vitamin Bl[median（P2.5, P97.5）] defined by age were as follows： 41.9 （45.6,88.1）nmmol/L for 0-3 year-old group,65.5（45.6,98.4）nmol/L for 3-5 year-old group,72.9（46.3,105.8） for 5-17 year-old group and 80.6（46.7,115.9） for the adult group. The levels of serum vitamin B2 were as follows：285.6（197.3, 376.2）μg/L for 0- 5 year-old group,297.9（208,387.4）μg/L for 5-17 year-old group and 308.2（280.6,394.7） μg/L for the adult group. 3） Positive correlation was found between age and the level of serum vitamin B1 as well as that of serum vitamin B2. Conclusion Reference range for serum vitamin B1 for healthy children in Guangzhou is same among different age groups,while that for serum vitamin B2 need to be set up according two age groups by a five years old.