儿童反复呼吸道感染与血清维生素A、D、E水平的相关性研究

Association between the levels of serum vitamin A,D,E and recurrent respiratory tract infection in children

目的探讨儿童反复呼吸道感染与患儿血清维生素A、D、E水平的相关性研究,为临床治疗提供科学依据。方法选取2015年在长春市儿童医院参加儿童保健,近3个月反复呼吸道感染病史患儿66例为病例组;选取前来参加儿童保健的健康儿童66例为对照组。用高效液相色谱法检测维生素A、D、E的水平。结果不同年龄组儿童患反复呼吸道感染疾病的差异有统计学意义(χ~2=13.516,P=0.001),病例组儿童血清维生素A水平和缺乏率明显低于对照组(t=3.536,P=0.001;χ~2=16.901,P=0.000),病例组儿童血清25(OH)D、维生素E水平和缺乏率与对照组比较差异无统计学意义(P>0.05)。结论反复呼吸道感染可能与维生素A缺乏有关,建议加强营养教育和宣传,指导儿童家长进行科学喂养,定期监测维生素A、D、E水平并适量补充维生素。

Objective To examine the association between the levels of serum vitamin A,D,E with recurrent respiratory tract infection （RRTI） in children and to provide evidence for clinical diagnosis and treatment. Methods Totally 66 children with recurrent respiratory tract infections and 66 health children were selected as cases and controls in Child Heahhcare Department of Changchun Children＇s Hospital in 2015, respectively. The levels of vitamin A, D, E were detected using high performance liquid chromatography and tandem mass spectrometry. Results The prevalences of RRTI in different age groups were significantly different （χ2 = 13. 516 ,P=0. 001）. Cases had significantly lower serum level of vitamin A and higher rate of vitamin A deficiency than healthy controls （t=3. 536,P=0. 001;χ2 =16. 901,P=0. 000）. But serum levels of vitamin D and E were not significantly different between cases and controls,as well as rate of vitamin D deficiency and vitamin E deficiency（P〉0.05）. Conclusions Recurrent respiratory tract infection may be related to vitamin A deficiency. It is recommended to strengthen nutrition health education and advocacy activities, such as providing scientific feeding guidance to the parents and vitamin supplements to children,monitoring the levels of vitamin A,D, E in children regularly.