支气管哮喘患者呼出气一氧化氮与血嗜酸性粒细胞数量及比例和免疫球蛋白E的相关性分析

Correlation between Fractional Exhaled Nitric oxide （FeNO） and Blood Eos, Eos%, Serum TIgE in Patients with Bronchial Asthma

【目的】探讨支气管哮喘（简称哮喘）患者的呼出气一氧化氮（FeNO）与血嗜酸性粒细胞（Eos）及血Eos占白细胞总数的百分比（Eos％）和血总免疫球蛋白E（TIgE）的相关性。【方法】选择2014年10月至2015年9月本院收治的哮喘患者80例为观察组，随机抽取同期来本院进行正常体检的健康志愿者80例为对照组，比较两组的呼出气FeNO、血Eos、Eos％及TIgE水平，并分析FeNO水平与其他指标的相关性。【结果】观察组呼出气FeNO为（51．48±13．09）ppb，明显高于对照组（11．29±4．37）ppb；观察组的哮喘控制测试（ACT）评分为（15．39±3．21）分，明显低于对照组（23．64±4．29）分，其差异均有统计学意义（P〈0．05）；观察组EOS、Eos％及TIgE水平分别为（264．28±32．19）×10^6／L、（6．39±1．21）％、（134．38±19．73）kU／L，均明显高于对照组[（67．49±9．74）×10^6／L、（1．21±0．59）％、（92．10±11．49）kU／L]，差异均有显著性（均P〈0．05）；相关性分析显示，FeNO水平与TIgE水平无相关性（P〉0．05），与Eos计数和Eos％水平呈正相关性（P〈0．05）。【结论】呼出气FeNO检测作为一种无创性操作检查，其检测结果能够直接反映哮喘患者的慢性气道炎症状况，尤其是对于嗜酸粒细胞性炎症反应，且有利于评估哮喘疾病严重程度，值得临床推广应用。

[Objective]To explore the correlation between fractional exhaled nitric oxide （FeNO） , blood eosinophilic granulocyte （Eos）and Eos% with serum total immunoglobulin E （TIgE） in patients with bronchial asthma. [Methods]Eighty bronchial asthma patients hospitalized in our hospital from October, 2014 to September,2015 were selected as the observation group; meanwhile, 80 check-up volunteers in the above-men- tioned hospital were selected randomly as the control group. Exhaled FeNO, blood Eos, Eos% and TIgE levels were compared between the two groups to analyze the correlation between FeNO levels and other indicators.[Results]The level of FeNO in the observation group （51.48±13.09） was significantly higher than that of the control group（ll.29±4.37）ppb, while the score of ACT in the observation group （15.39±3.21） was significantly lower than that of the control group（23.64±4.29）, with statistically significant differences between the two groups（ P 〈0.05）. The levels of Eos, Eos% and TIgE in the observation group were （264.28± 32.19）×10^6/L, （6.39 ± 1.21 ） % and （ 134.38± 19.73 ） kU/L respectively, which were all significantly higher than those of the control group [-（67.49± 9.74） ）〈 106/L,（1.21± 0.59）% ,（92.10± 11.49）kU/L]（ P 〈0.05）. Regression analysis showed that the level of FeNO did not correlated with the level of TIgE （ P 〉0.05）, and positively correlated with Eos count and Eos% level （ P 〈0.05）. [Conclusions] As a noninvasive examination, the test results FeNO detection can directly reflect the situation of chronic airway inflammation of allergic asthma patients, especially in the inflammatory response of Eos, and it is also conducive to accurately evaluate the severity of allergic asthma. Therefore, it is worthy of clinical application.