晚期胃癌患者组织中PVT1、Her-2基因表达水平与临床病理的关系

Correlation between the Expression of PVT1 and Her-2 Genes and Clinical Pathology in Patients with Advanced Gastric Cancer

【目的】探讨晚期胃癌患者组织中人浆细胞瘤转化迁移基因1（PVT1）、人表皮生长因子受体-2（Her-2）表达水平及其与胃癌临床病理特征的关系。【方法】采用免疫组织化学染色法检测分析本院收治的80例经病理确诊的晚期胃癌患者癌组织及癌旁正常组织中PVT1、Her-2表达水平。【结果】胃癌组织标本PVT1高表达率、Her-2阳性表达率均明显高于较癌旁组织（P〈0．05）；印戒细胞患者PVT1高表达率（81．25％）、Her-2阳性率（75．00％）明显高于乳头状腺癌、管状腺癌、低分化腺癌（P〈0．05）；相关性分析显示PVT1高表达、Her-2阳性表达与胃癌TNM分期、淋巴结转移呈正相关（P〈0．05），与细胞分化程度呈负相关（P〈0．05），但与患者性别、年龄无相关性（P〉0．05）。【结论】晚期胃癌患者组织中PVT1、Her2基因表达水平与胃癌TNM分期、淋巴结转移、细胞分化、临床病理有明显相关性，临床可据此为晚期胃癌患者选择合理手术方案。

[Objective] To investigate the correlation between the expression of human plasmacytoma transformation and migration gene 1 （PVT1） and human epidermal growth factor receptor-2 （Her-2） and clinical pathology in patients with advanced gastric cancer. [Methods] Eighty cases of advanced gastric cancer diagnosed by pathology and the expression level of PVT1 and Her-2 in normal tissues adjacent to cancer were detected by immunohistochemical staining.[Results]The high expression rate of PVT1 and the positive expression rate of Her-2 in gastric cancer tissues were significantly higher than those in the adjacent tissues （ P 0.05）. The high expression rate of PVT1 and positive rate of Her-2 in patients with signet ring cells （81.25%, 75.00%） were significantly higher than those in patients with papillary adenocarcinoma, tubular adenocarcino- ma and poorly differentiated adenocarcinoma （ P 〈0.05）. Spearman correlation analysis showed that high expression of PVT1 and positive expression of Her-2 were positively correlated with TNM stage of gastric cancer and lymph node metastasis（ P 〈0.05）, and negatively correlated with the degree of ceil differentiation , but there was no correlation with gender and age （ P 〉0.05）. [Conclusion]The expression levels of PVT1 and Her-2 in patients with advanced gastric cancer are significantly correlated with TNM stage of gastric cancer, lymph node metastasis, cell differentiation and clinical pathology.