不同症型肠易激综合征患者血浆白细胞介素与肿瘤坏死因子的表达及其意义

Study on the Relationship the Expression of Interleukin and Tumor Necrosis Factor with Irritable Bowel Syndrome

【目的】4g讨不同症型肠易激综合征（IBS）患者血清中白细胞介素-1β（IL—1β）、IL-10、IL-18和肿瘤坏死因子-α（TNF-α）的表达变化及在IBS发病机制中的作用。【方法】72例IBS患者根据症状类型分为腹泻型IBS组（A组）和便秘型IBS组（B组），采用ELISA法检测比较患者血清中细胞因子IL-1β、IL-10、IL-18和TNF-α含量。【结果】A组和B组IL-1β、IL-10、IL-18和TNF-α在血清中的表达与对照组比较均明显升高，且差异有显著性（P〈0．05）。A组TNF—α水平明显高于B组，且差异有显著性（P〈0．05）。A组和B组IL-1β、IL10、IL-18在血清中的表达相比较差异均无显著性（P〉0．05）。【结论】促炎性细胞因子和抗炎性细胞因子的失衡可能与IBS患者腹泻、腹胀、排便习惯改变等临床症状的出现具有一定的相关性。

[Objective]To investigate the changes of serum interleukin -1β（IL-1β）.IL-10.IL-18 and tumor necrosis factor alpha （TNF-） expression in patients with irritable bowel syndrome （IBS） and their roles in the pathogenesis of IBS.[Methods] Seventy-two patients with IBS were divided into diarrhea type group IBS （group A） and constipation type IBS group （B group） according to the symptom type. The levels of cytokines IL-1β, IL-10, IL-18 and TNF-αin serum were detected by ELISA.[Results]The expression of IL-1β. IL-10.IL-18 and TNF-αin serum of the Group A and the Group B was significantly higher than those of the control group, and the difference was significant （ P 〈0.05）. The level of TNF-αin the Group A was higher than that in the Group B, and the difference was significant （ P 〈0.05）. There was no significant difference in the expression of IL-1β, IL-10, IL-18 in serum between the two groups （ P 〈0.05）.[Gonclusion]The imbalance between proinflammatory cytokines and anti-inflammatory cytokines may be related to the clinical symptoms such as diarrhea, abdominal distension, and changes in bowel habits in IBS patients.