新辅助化疗及联合脏器切除术治疗局部进展期胃癌疗效分析

Efficacy analysis of neoadjuvant chemotherapy and combined multiple visceral resection for locally advanced gastric carcinoma

目的:探讨在局部进展期胃癌的治疗中采用新辅助化疗联合脏器切除术的临床应用效果。方法:选取65例临床分期为局部进展期胃癌患者,其中35例作为试验组,采用新辅助化疗联合脏器切除胃癌根治术,术前辅助化疗及术后化疗方案为SOX;30例为对照组,直接采用联合脏器切除胃癌根治术,术后接受SOX方案辅助化疗,对两组治疗方法的近期疗效及并发症情况进行比较。结果:试验组和对照组的3年生存率间差异具有统计学意义(P<0.05),两组手术并发症发生率比较,差异无统计学意义(P>0.05),两组均无手术相关死亡病例。结论:术前、术后辅助化疗联合脏器切除胃癌根治术可改善局部进展期胃癌患者的预后,并发症风险可控,值得临床推广。

Objective To explore the efficacy of neoadjuvant chemotherapy and combined multiple visceral resection for lo-cally advanced gastric carcinoma. Method 65 locally advanced gastric carcinoma patients were selected and divided into two groups. 35 patients were as the experimental group and treated by neoadjuvant chemotherapy and combined multiple visceral re-sections. The adjuvant chemotherapy protocol preoperative and postoperative was SOX. 30 patients were as the control group,the patients were directly treated by combined multiple visceral resection and postoperative adjuvant chemotherapy. The efficacy and complications of the two groups were compared. Results The 3 - years survival rate of experimental group was higher than control group,the difference was statistically significant （P 〈 0. 05 ）. The differences of operative complications rates of the two groups were not significant（ P 〉 0. 05）. There were no procedure - related deaths. Conclusion Preoperative and postoperative adjuvant chemotherapy combined with radical resection of gastric cancer can improve the prognosis of patients with locally advanced gastric cancer. The complication risks are controllable. It is worth for generalization.