甘油三酯与臂踝动脉脉搏波传导速度的关系

Relationship Between Blood Triglyceride Level and Brachial-ankle Pulse Wave Velocity in Relevant Population

目的:探讨甘油三酯与臂踝动脉脉搏波传导速度(baPWV)的关系。方法:选择开滦研究人群(卒中队列5 219例、老年人群队列1 754例、妊娠高血压队列1 561例、外周血管疾病筛查人群14 088例)共22 622例完成baPWV检测,采用偏相关分析甘油三酯与baPWV的相关性,多因素线性回归、多因素Logistic回归分析甘油三酯对baPWV的影响。结果:在22 622例人群中,排除甘油三酯缺失909例,最终纳入研究队列的为21 713例。结果显示,随着甘油三酯水平的增加,平均baPWV水平和baPWV≥1400 cm/s的检出率均呈上升趋势,偏相关分析结果表明甘油三酯与baPWV之间呈正相关(r=0.235),校正年龄、性别后甘油三酯与baPWV仍呈正相关(r=0.080)。Logistics回归分析表明,校正其他混杂因素后甘油三酯第二分位组、第三分位组、第四分位组与甘油三酯第一分位组相比均是baPWV≥1 400 cm/s的危险因素,比值比及95%可信区间分别为1.161(1.035~1.302)、1.312(1.165~1.476)、1.652(1.463~1.865)。结论:甘油三酯与脉搏波传导速度呈正相关,甘油三酯与脉搏波传导速度独立关联。

Objective： To investigate the relationship between blood triglyceride （TG） level and brachial-ankle pulse wave velocity （baPWV） in relevant population. Methods： A total of 22622 participants in Kailuan area were enrolled and divided into 4 ranks： Stroke rank, n=5219, Aged rank n= 1754, Pregnancy hypertension Rank, n=1561 and Peripheral vascular diseases rank, n=14088. All participants finished baPWV examination. The relationship between TG and baPWV was studied by partial correlation analysis, the impact of TG on baPWV was assessed by multivariate linear regression and multivariate Logistic regression analysis. Results： There were 21713 subjects finally enrolled for cohort study and 909 subjects excluded for missing TG information. With elevated TG levels, the average baPWV and the detection rate of baPWV_〉1400 cm/s showed the increasing trend. Partial correlation analysis presented that TG level was positively related to baPWV, r=0.235; with adjusted age and gender, TG was still positively related to baPWV, r=0.080. Logistic regression analysis indicated that with other adjusted confounding factors, compared with the first quartile of TG, the second quartile, third quartile and fourth quartile of TG were the risk factors for baPWV≥1400 cm/s, OR=1.161, 95% CI （1.035-1.302）, OR=1.312, 95% （1.165-1.476） and OR=1.652, 95% CI （1.463-1.865） respectively. Conclusion： Blood TG level was positively and independently related to baPWV in relevant population.