影像学技术应用于阿尔茨海默病早期诊断的研究进展

Advance in Imaging Techniques for Early Diagnosis of Alzheimer's Disease(review)

对阿尔茨海默病(AD)的临床诊断主要根据临床病史,但敏感性和准确性有限。正电子发射计算机断层显像技术可通过葡萄糖代谢成像以及生物标记物成像较为准确地早期诊断AD;磁共振成像技术则通过结构成像以及功能成像,为AD的早期诊断和鉴别诊断提供基础。近年来,多模态成像技术将放射学与核医学紧密结合,可更为准确地诊断AD。

At present, the clinical diagnosis of Alzheimer＇s disease （AD） is mainly based on clinical history, however, the sensitivity and accuracy is limited. Positron emission computed tomography can accurately diagnose AD early by glucose metabolism imaging and bio- marker imaging. Magnetic resonance imaging provides the basis for early diagnosis and identification of AD by structural imaging and func- tional imaging. In recent years, the multi-modality imaging technology closely combines radiology and nuclear medicine, which can more accurately diagnose AD.