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散乱蛋白对神经发生影响的研究进展 被引量:1

Role of Dishevelled in Neurogenesis(review)
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摘要 散乱蛋白(Dvl)是广泛存在于人体组织内的一种蛋白,含有三个结构域:散乱蛋白轴蛋白(DIX)结构域、突触后密集区蛋白-95/大型肿瘤抑制基因/紧密连接跨膜蛋白(PDZ)结构域、散乱蛋白/Egl-10/普列克底物蛋白(DEP)结构域。散乱蛋白通过不同的结构域参与Wnt信号传导,影响神经系统发育与神经损伤后神经发生。 Dishevelled (Dvl) is a kind of protein widely existing in human tissue, containing three structural domains: Dishevelled and Axin (DIX); postsynaptic density protein-95, disc large tumour suppressor, zonula occludens-1 (PDZ); and Dishevelled, Egl-10 and pleck- strin (DEP). Dvl participates in the Wnt signaling through different structure domains to play a role in nervous system development and neurogenesis after nerve injury.
作者 王志敏 梅彩琴 WANG Zhi-min MEI Cai-qin(Qujing Medical College, Qujing, Yunnan 655000, Chin)
出处 《中国康复理论与实践》 CSCD 北大核心 2017年第5期548-552,共5页 Chinese Journal of Rehabilitation Theory and Practice
关键词 散乱蛋白 WNT信号 神经发生 综述 Dishevelled Wnt signaling neurogenesis review
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