复方甘草片吞服与含服的疗效和不良反应发生率分析

The efficacy and adverse reactions incidence of the compound licorice tablets via oral medication and keeping-in-mouth

目的探讨复方甘草片吞服与含服的疗效及患者不良反应发生情况。方法选择2015年1月至2016年6月我院收治的呼吸道感染患者60例作为研究对象,所有患者均给予复方甘草片治疗,根据患者给药途径不同将其分为吞服组(采取吞服复方甘草片治疗,n=30)和含服组(采取含服复方甘草片治疗,n=30),统计两组患者的治疗效果及不良反应发生情况。结果含服组患者用药治疗总有效率为96.7%,与吞服组80.0%相比明显更高(P<0.05);含服组患者咳嗽症状消失时间、咳痰症状消失时间与吞服组相比明显较少(P<0.05);含服组患者不良反应总发生率为6.7%,明显低于吞服组的30.0%(P<0.05)。结论复方甘草片吞服与含服的疗效及患者不良反应发生情况存在明显差异,采取含服用药可有效提升治疗效果,促进患者临床症状消失,并能降低不良反应发生率。

Objective To investigate the curative effect and adverse reaction of compound liquorice tablets via oral medication and keeping-in-mouth. Methods From January 2015 to June 2016, 60 cases of patients with respiratory tract infection were selected as research objects, and were all given compound liquorice tablets treatment, according to different administration routes, the patients were divided into swallow group （treated with swallowing compound liquorice tablets, n=30） and keeping-in-mouth group （keeping compound liquorice tablets in mouth, n=30）. The curative effects and incidence of the adverse reactions between the two groups were recorded. Results The total effective rate of the keeping-in-mouth group was 96.7%, which was significantly higher than 80.0% of the swallow group （P〈0.05）; the cough and coughing up phlegm symptoms disappearing time of the keeping-in-mouth group were less than those of the swallow group （P〈0.05）; the total incidence of adverse reactions in the keeping-in-mouth group was 6.7%, which was significantly lower than 30.0% of the swallow group （P〈0.05）. Conclusion There is obvious difference in the curative effect and adverse reaction of compound liquorice tablets via swallowing and administering. Keeping compound liquorice tablets in mouth can effectively improve the patients＂ treatment effect, and it is conductive to the clinical symptoms disappearing, and reduce the incidence of adverse reactions.