联合应用头孢曲松钠、奥曲肽与奥美拉唑治疗肝硬化上消化道出血的临床效果

Clinical effect of combined use of ceftriaxone sodium, octreotide and omeprazole in the treatment of liver cirrhosis upper gastrointestinal bleeding

目的观察肝硬化合并上消化道出血患者采用头孢曲松钠、奥曲肽、奥美拉唑联合治疗的临床效果。方法选取我院收治的90例肝硬化合并上消化道出血患者为研究对象,随机分为对照组和观察组,各45例。对照组患者采用奥曲肽加奥美拉唑治疗,观察组患者采用头孢曲松钠加奥曲肽加奥美拉唑治疗,比较两组患者的治疗效果。结果治疗后,观察组患者总有效率为93.3%,显著高于对照组的64.4%(P<0.05);观察组患者的平均止血时间、住院时间、48 h再出血率明显优于对照组(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论应用头孢曲松钠加奥曲肽加奥美拉唑治疗肝硬化合并上消化道出血,临床效果显著,值得临床推广应用。

Objective To observe the clinical effect of the combined use of ceflriaxone sodium, octreotide and omeprazole in the treatment of liver cirrhosis upper gastrointestinal bleeding. Methods Ninety cases of patients with liver cirrhosis upper gastrointestinal bleeding were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group used the octreotide plus omeprazole treatment, while the observation group accepted combined use of ceftriaxone sodium, octreotide and omeprazole. The clinical effects of the two groups were compared. Results After treatment, the total effective rate of the observation group was 93.3%, which was higher than 64.4% of the control group （P〈0.05）. The average bleeding time, length of hospital stay and bleeding rate after 48 h of the observation group were better than those of the control group （P〈0.05）. There was no significant difference on the rate of adverse reactions between two groups （P〉0.05）. Conclusion Combined use of ceftriaxone sodium, octreotide and omeprazole has significant clinical effect in the treatment of liver cirrhosis upper gastrointestinal bleeding, which is worthy of clinical application and popularization.