氯吡格雷联合小剂量尿激酶在进展性脑梗死中的临床效果观察

Clinical observation of clopidogrel combined with low-dose urokinase in progressive cerebral infarction

目的观察氯吡格雷联合小剂量尿激酶治疗进展性脑梗死的临床效果及对患者神经功能、生活质量的影响。方法将80例进展性脑梗死患者随机分为对照组和观察组,每组40例。对照组采用常规方法联合小剂量尿激酶治疗,观察组在对照组的基础上,给予氯吡格雷治疗。比较两组治疗效果,治疗前、后神经功能和生活质量改善情况及不良反应发生情况。结果观察组的总有效率为95.0%,明显高于对照组的75.0%(P<0.05)。观察组治疗后神经功能缺损评分与日常生活能力评分显著优于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合小剂量尿激酶治疗进展性脑梗死可显著改善预后,降低神经损伤程度,值得临床推广应用。

Objective To observe the clinical effect of clopidogrel combined with low-dose urokinase and its influence on patients＂ nerve function, quality of life in patient with progressive cerebral infarction. Methods Eighty patients with progressive cerebral infarction were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with routine therapy in combination with small dose of urokinase, while the observation group was treated with clopidogrel on the basis of the control group. The treatment effect, neural function and quality of life before and after treatment, the incidence of adverse reaction in the two groups were compared. Results The total effective rate of the observation group was 95.0%, which was significantly higher than 75.0% of the control group, the difference was statistically significant （P〈0.05）. The scores of neurological deficit and the daily life ability of the observation group were significantly better than those of the control group （P〈0.05）. The incidence of adverse reactions was statistically analyzed, and the difference was not statistically significant （P〉0.05）. Conclusion Clopidogrel in combination with small dose of urokinase in treatment of progress cerebral infarction can significantly improve the prognosis, reduce the degree of nerve injury, which is worthy of clinical popularization and application.