阵发性房颤患者经胺碘酮联合缬沙坦治疗的效果观察

Effect observation of amiodarone combined with valsartan on patients with paroxysmal atrial fibrillation

目的探讨阵发性房颤患者经胺碘酮联合缬沙坦治疗的临床效果。方法选择2012年1月至2014年12月在我院接受治疗的175例阵发性房颤患者为研究对象,随机分为观察组(88例)和对照组(87例)。观察组患者采用胺碘酮联合缬沙坦治疗,对照组患者单纯采用胺碘酮治疗,对比两组患者的治疗效果。结果观察组患者各时间段的窦性心律维持率均明显高于对照组患者,差异具有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异不显著(P>0.05)。结论采用胺碘酮联合缬沙坦治疗阵发性房颤能够有效维持窦性心律,且不会增加不良反应,安全可靠,值得推广使用。

Objective To explore the clinical effect of amiodarone combined with valsartan on patients with paroxysmal atrial fibrillation. Methods One hundred and seventy-five patients with paroxysmal atrial fibrillation admitted in our hospital from January 2012 to December 2014 were selected and randomly divided into observation group （n=88） and control group （n-87）. The observation group was treated with amiodarone combined with valsartan, the control group was treated with amiodarone. The treatment effects of the two groups were compared. Results The maintenance rate of sinus rhythm in the observation group was significantly higher than that in the control group, the difference was statistically significant （P〈0.05）. There was no significant difference on the incidence rate of adverse reactions between the two groups （P〉0.05）. Conclusion Amiodarone combined with valsartan in the treatment of paroxysmal atrial fibrillation can effectively maintain sinus rhythm, and does not increase the incidence of adverse reactions. It＇s safe and reliable, which is worthy of application and popularization in clinic.