N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期患者的治疗效果及对氧化应激的影响

Effect of N-acetylcysteine on the treatment of AECOPD in patients with its effect on oxidative stress

目的探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者采用N乙酰半胱氨酸治疗的临床效果及对患者氧化应激水平的影响作用。方法选取商丘市第一人民医院呼吸内科2013年6月至2015年6月收治的AECOPD患者220例，采用抽签法进行随机分组，试验组和对照组各110例，2组患者均给予常规治疗措施，试验组同时给予N-乙酰半胱氨酸治疗，疗程4周。结果治疗前，2组患者的GSH-ST活力、血清抑制羟自由基能力、抗超氧阴离子能力测定值差异无统计学意义（P〉0．05）；治疗后，试验组患者的GSH-ST活力、血清抑制羟自由基能力、抗超氧阴离子能力显著的高于对照组（P〈O．05）；治疗前，2组患者的PaO2、PaCO2测定值差异无统计学意义（P〉0．05）；治疗后，试验组患者的PaO2[（69．42±4．88）mmHg]显著的高于对照组[（64．57±5．92）mmHg]，PaCOz水平[（39．52±1．88）mmHg]显著的低于对照组[（41．73±1．96）mmHg]（P〈0．05）；治疗前，2组患者的FEV1％pred、FEV-／FVC测定值差异无统计学意义（P〉O．05）；治疗后，试验组患者的FEV1％pred、FEV。／FVC显著的高于对照组（P〈0．05）。结论AECOPD患者采用N-乙酰半胱氨酸治疗能显著的改善抗氧化能力，有利于提高治疗效果。

Objective To investigate the clinical effect of N-acetylcysteine in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and its effect on the level of oxidative stress in patients with AECOPD. Methods Two hundred and twenty cases of AECOPD patients selected in respiratory department of Shangqiu First People＇s Hospital in 2013 June 2015 in June, the draw method were randomly divided into two groups, experimental group and control group, each of 110 cases, two groups of patients were given conventional treatment, experimental group while giving N-acetyl cysteine treatment, a course of 4 weeks. Results Before the treatment, the activity of GSH ST in serum of the two groups of patients, inhibit the ability of hydroxyl radical, anti superoxide anion activity determination showed no significant difference （ P 〉0.05）. After treatment, the serum GSH-ST activity, patients in the experimental group, inhibition of hydroxyl radical superoxide anion capacity was significantly higher than that of control group （ P 〈0.05）. Before the treatment, two groups of patients with PaOz, PaCO2 was no statistically significant difference （ P 〉0.05）. After treatment, the test group of patients with PaO2 [（69.42~4.88） mmHg] was significantly higher than that of control group [（64.57±5.92） mmHg] （ P 〈0.05）, the level of PaCO2 [（39.52 ±1.88） mmHg] was significantly lower than that of control group [（41.73± 1.96） mmHg] （ P %0.05）. The two groups of patients before treatment, FEV1 Glared, FEV1/ FVC was no statistically significant difference （ P ~0.05）. After treatment, patients in the experimental group FEV1 % pred and FEVI/FVC were significantly higher than that of control group （ P〈0.05）. Conclusions AECOPD patients with N-acetyl cysteine treatment can significantly improve the antioxidant capacity, is conducive to improve the treatment effect,